Effect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized rats

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dc.contributor.authorMatsubara, B.B. [UNESP]
dc.contributor.authorFranco, M.
dc.contributor.authorJanicki, J.S.
dc.contributor.authorMatsubara, L.S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversity of South Carolina
dc.date.accessioned2014-05-20T13:33:37Z
dc.date.available2014-05-20T13:33:37Z
dc.date.issued2010-05-01
dc.description.abstractIt has been recently shown that calcium channel blockers might have a protective effect on cardiac fibrogenesis induced by aldosterone. The objective of this study was to evaluate the protective effect of felodipine, a dihydropyridine calcium channel blocker, against heart and kidney damage caused by aldosterone-high sodium intake in uninephrectomized rats. Wistar rats were divided into three groups: CNEP (uninephrectomized + 1% NaCl in the drinking water, N = 9); ALDO (same as CNEP group plus continuous infusion of 0.75 µg/h aldosterone, N = 12); ALDOF (same as ALDO group plus 30 mg·kg-1·day-1 felodipine in the drinking water, N = 10). All results were compared with those of age-matched, untreated rats (CTL group, N = 10). After 6 weeks, tail cuff blood pressure was recorded and the rats were killed for histological analysis. Blood pressure (mmHg) was significantly elevated (P < 0.05) in ALDO (180 ± 20) and ALDOF (168 ± 13) compared to CTL (123 ± 12) and CNEP (134 ± 13). Heart damage (lesion scores - median and interquartile range) was 7.0 (5.5-8.0) in ALDO and was fully prevented in ALDOF (1.5; 1.0-2.0). Also, left ventricular collagen volume fraction (%) in ALDOF (2.9 ± 0.5) was similar to CTL (2.9 ± 0.5) and CNEP (3.4 ± 0.4) and decreased compared to ALDO (5.1 ± 1.6). Felodipine partially prevented kidney injury since the damage score for ALDOF (2.0; 2.0-3.0) was significantly decreased compared to ALDO (7.5; 4.0-10.5), although higher than CTL (null score). Felodipine has a protective effect on the myocardium and kidney as evidenced by decreased perivascular inflammation, myocardial necrosis and fibrosis.en
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Clínica Médica
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Patologia
dc.description.affiliationUniversity of South Carolina Department of Cell and Developmental Biology and Anatomy
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Clínica Médica
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent506-514
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2010007500037
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 5, p. 506-514, 2010.
dc.identifier.doi10.1590/S0100-879X2010007500037
dc.identifier.fileS0100-879X2010000500013.pdf
dc.identifier.issn0100-879X
dc.identifier.lattes6990977122340795
dc.identifier.lattes6309835137998766
dc.identifier.scieloS0100-879X2010000500013
dc.identifier.urihttp://hdl.handle.net/11449/11514
dc.identifier.wosWOS:000277830900013
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectAldosteroneen
dc.subjectDihydropyridineen
dc.subjectFibrinoid necrosisen
dc.subjectVascular remodelingen
dc.subjectHypertensionen
dc.subjectMyocardial remodelingen
dc.titleEffect of felodipine on myocardial and renal injury induced by aldosterone-high salt hypertension in uninephrectomized ratsen
dc.typeArtigo
dcterms.rightsHolderAssoc Bras Divulg Cientifica
unesp.author.lattes6990977122340795
unesp.author.lattes6309835137998766
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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