Long-term follow-up of patients with intestinal neuronal dysplasia type B

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dc.contributor.authorDe Arruda Lourenção, Pedro Luiz Toledo [UNESP]
dc.contributor.authorOrtolan, Erika Veruska Paiva [UNESP]
dc.contributor.authorRosa, Laura Luiza Minelli [UNESP]
dc.contributor.authorAngelini, Marcos Curcio [UNESP]
dc.contributor.authorTerra, Simone Antunes [UNESP]
dc.contributor.authorRodrigues, Maria Aparecida Marchesan [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:13:39Z
dc.date.available2018-12-11T17:13:39Z
dc.date.issued2017-07-01
dc.description.abstractIntestinal neuronal dysplasia type B (IND-B) is a pathological entity of the group of gastrointestinal neuromuscular diseases characterized by complex alterations in the enteric nervous system. Patients typically present with intestinal constipation, sometimes complicated by episodes of intestinal obstruction. The 2 therapeutic modalities include conservative clinical treatment and surgical treatment. Nevertheless, the results of the different therapeutic modalities are conflicting, and follow-up studies are scarce and include only a limited number of patients. This is a single-center, ambispective, observational, longitudinal, and comparative follow-up study to compare the results of conservative clinical and surgical treatments in patients with IND-B. Sixty-three patients (<15 years) who received this diagnosis will be included. These patients will be divided into 2 groups according to the type of treatment that they previously received: 29 patients in the surgical treatment group and 34 patients in the conservative treatment group. Previous data will be recovered from the medical records of the study patients, including signs and symptoms present at the time of diagnosis, particularly those related to bowel habits, and treatments undergone. Later, these patients will be invited to participate in a semistructured interview during which aspects related to the long-term functional results of the bowel habit and quality of life will be investigated after a minimum interval of 5 years posttreatment. This project aims to assess the long-term clinical evolution of patients diagnosed with IND-B and compare the results obtained following conservative clinical and surgical treatments. This protocol will provide sufficient data to analyze the long-term clinical outcome obtained through the 2 treatment modalities proposed for patients with IND-B.en
dc.description.affiliationDiscipline of Pediatric Surgery Department of Surgery and Orthopedics Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mario Rubens Guimaraes Montenegro, s/n
dc.description.affiliationBotucatu Medical School São Paulo State University (UNESP)
dc.description.affiliationDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)
dc.description.affiliationUnespDiscipline of Pediatric Surgery Department of Surgery and Orthopedics Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mario Rubens Guimaraes Montenegro, s/n
dc.description.affiliationUnespBotucatu Medical School São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1097/MD.0000000000007485
dc.identifier.citationMedicine (United States), v. 96, n. 28, 2017.
dc.identifier.doi10.1097/MD.0000000000007485
dc.identifier.file2-s2.0-85026315381.pdf
dc.identifier.issn1536-5964
dc.identifier.issn0025-7974
dc.identifier.lattes9204865367532468
dc.identifier.lattes4428524305554124
dc.identifier.orcid0000-0002-8753-646X
dc.identifier.orcid0000-0002-9697-3450
dc.identifier.scopus2-s2.0-85026315381
dc.identifier.urihttp://hdl.handle.net/11449/174965
dc.language.isoeng
dc.relation.ispartofMedicine (United States)
dc.relation.ispartofsjr0,799
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectintestinal chronic constipation
dc.subjectintestinal dysganglionosis
dc.subjectintestinal neuronal dysplasia type B
dc.titleLong-term follow-up of patients with intestinal neuronal dysplasia type Ben
dc.typeArtigo
unesp.author.lattes9204865367532468[1]
unesp.author.lattes4428524305554124(2)
unesp.author.orcid0000-0002-8753-646X[1]
unesp.author.orcid0000-0002-9697-3450(2)

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