BUBR1 expression in benign oral lesions and squamous cell carcinomas: Correlation with human papillomavirus

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dc.contributor.authorLira, Regia C. P.
dc.contributor.authorMiranda, Fabiana A.
dc.contributor.authorGuimaraes, Marcia C. M.
dc.contributor.authorSimoes, Renata T.
dc.contributor.authorDonadi, Eduardo A.
dc.contributor.authorSoares, Christiane P. [UNESP]
dc.contributor.authorSoares, Edson G.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSanta Casa Belo Horizonte
dc.date.accessioned2014-05-20T13:23:56Z
dc.date.available2014-05-20T13:23:56Z
dc.date.issued2010-04-01
dc.description.abstractOral squamous Cell carcinoma (OSCC) is the most common head and neck cancer. Only in Brazil, the estimate is for 14,160 new cases in 2009. HPV is associated with increasing risk of oral cancer, but its role in carcinogenesis is still controversial. BUBR1, all important protein in the mitotic spindle assembly checkpoint (SAC), has been associated with some virus-encoded proteins and cancer. The aim of the present study was to evaluate the expression of BUBR1 in non-malignant oral lesions and OSCC with and without metastasis associated with HPV infection. We performed immunohistochemistry for BUBR1 in 70 OSCC biopsies divided into three groups (in situ tumors, invasive tumors without metastasis and invasive tumors with metastasis) with their respective lymph nodes from samples with metastasis and in 16 non-malignant oral lesions. PCR was performed in order to detect HPV DNA. Significantly higher BUBR1 expression associated with shorter survival (p=0.0479) was observed in malignant lesions. There was also it significant correlation (r=1.000) with BUBR1 expression in lesions with metastasis and their lymph nodes. Ninety percent of OSCC and 100% of benign lesions were HPV positive. HPV16 and HVP18 were present in 13 and 24% of HPV-positive OSCC samples, respectively. HPV was more prevalent (76%) in samples with a high BUBR1 expression and the absence of viral DNA had no influence oil BUBR1 expression. These findings suggest that HPV could be associated with overexpression of BUBR1 in OSCC. but not in benign oral lesions.en
dc.description.affiliationUniv São Paulo, Dept Patol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Div Imunol Clin, Fac Med Ribeirao Preto, Dept Clin Med, BR-14048900 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho UNESP, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSanta Casa Belo Horizonte, Nucleo Posgrad & Pesquisa, BR-3015022 Belo Horizonte, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho UNESP, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1027-1036
dc.identifierhttp://dx.doi.org/10.3892/or_00000729
dc.identifier.citationOncology Reports. Athens: Spandidos Publ Ltd, v. 23, n. 4, p. 1027-1036, 2010.
dc.identifier.doi10.3892/or_00000729
dc.identifier.issn1021-335X
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/7314
dc.identifier.wosWOS:000275802000019
dc.language.isoeng
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofOncology Reports
dc.relation.ispartofjcr2.976
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBUBR1en
dc.subjectHPVen
dc.subjectoral squamous cell carcinomaen
dc.titleBUBR1 expression in benign oral lesions and squamous cell carcinomas: Correlation with human papillomavirusen
dc.typeArtigo
dcterms.licensehttp://www.spandidos-publications.com/pages/static.jsp?content=info_for_authors
dcterms.rightsHolderSpandidos Publ Ltd
unesp.author.lattes1768025290373669[6]
unesp.author.orcid0000-0002-9457-9601[5]
unesp.author.orcid0000-0002-1217-3852[1]
unesp.author.orcid0000-0003-1740-7360[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR