Chronopharmacological effects of growth hormone on the executive function and oxidative stress response in rats

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dc.contributor.authorFerrari, Carlos K. B.
dc.contributor.authorFrança, Eduardo Luzía [UNESP]
dc.contributor.authorMonteiro, Luciane A.
dc.contributor.authorSantos, Bruno L.
dc.contributor.authorPereira-Junior, Alfredo [UNESP]
dc.contributor.authorHonorio-França, Adenilda C. [UNESP]
dc.contributor.institutionFederal University of Mato Grosso (UFMT)
dc.contributor.institutionUniversity Center of Araxá (UNIARAXA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:45:19Z
dc.date.available2018-12-11T16:45:19Z
dc.date.issued2017-01-01
dc.description.abstractObjective(s): To investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. Materials and Methods: Fifty male Wistar rats (36-40 weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal GH-treated, and nocturnal GH-treated animals. Levels of Cu, Zn superoxide dismutase (Cu,Zn-SOD), and superoxide release by spleen macrophages were evaluated. For memory testing, adaptation and walking in an open field platform was used. GH-treated animals demonstrated better performance in exploratory and spatial open-field tests. Results: The latency time in both GH-treated groups was significantly lower compared with the latency time of the control groups. The diurnal GH treatment did not stimulate superoxide release but increased the CuZn-SOD enzyme levels. The nocturnal GH treatment did not influence the superoxide release and CuZn-SOD concentration. GH treatment also resulted in heart atrophy and lung hypertrophy. Conclusion: Growth hormone treatment improved the performance of executive functions at the cost of oxidative stress triggering, and this effect was dependent on the circadian period of hormone administration. However, GH treatment caused damaging effects such as lung hypertrophy and heart atrophy.en
dc.description.affiliationFederal University of Mato Grosso (UFMT)
dc.description.affiliationUniversity Center of Araxá (UNIARAXA)
dc.description.affiliationSão Paulo State University (UNESP)
dc.description.affiliationUnespSão Paulo State University (UNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent17-22
dc.identifierhttp://dx.doi.org/10.22038/ijbms.2017.8087
dc.identifier.citationIranian Journal of Basic Medical Sciences, v. 20, n. 1, p. 17-22, 2017.
dc.identifier.doi10.22038/ijbms.2017.8087
dc.identifier.issn2008-3874
dc.identifier.issn2008-3866
dc.identifier.scopus2-s2.0-85008196659
dc.identifier.urihttp://hdl.handle.net/11449/169314
dc.language.isoeng
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.ispartofsjr0,538
dc.relation.ispartofsjr0,538
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectChronopharmacology
dc.subjectExecutive function
dc.subjectGrowth hormone
dc.subjectSuperoxide anion
dc.subjectSuperoxide dismutase
dc.titleChronopharmacological effects of growth hormone on the executive function and oxidative stress response in ratsen
dc.typeArtigo

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