Evaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approach

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dc.contributor.authorGuiraldello, Rafael T. [UNESP]
dc.contributor.authorMartins, Marcelo L.
dc.contributor.authorMancera, Paulo F. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.date.accessioned2018-11-26T16:33:10Z
dc.date.available2018-11-26T16:33:10Z
dc.date.issued2016-08-15
dc.description.abstractWe present a mathematical model based on partial differential equations that is applied to understand tumor development and its response to chemotherapy. Our primary aim is to evaluate comparatively the efficacies of two chemotherapeutic protocols, Maximum Tolerated Dose (MTD) and metronomic, as well as two methods of drug delivery. Concerning therapeutic outcomes, the metronomic protocol proves more effective in prolonging the patient's life than MTD. Moreover, a uniform drug delivery method combined with the metronomic protocol is the most efficient strategy to reduce tumor density. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Bioestat, BR-18618689 Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Vicosa, Dept Fis, BR-36570900 Vicosa, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Bioestat, BR-18618689 Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFAPESP: 2013/08133-0
dc.description.sponsorshipIdFAPESP: 2009/15098-0
dc.description.sponsorshipIdFAPEMIG: APQ-04232-10
dc.description.sponsorshipIdCNPq: 306024/2013-6
dc.description.sponsorshipIdFUNDUNESP: 1886/009-13
dc.format.extent145-156
dc.identifierhttp://dx.doi.org/10.1016/j.physa.2016.03.019
dc.identifier.citationPhysica A-statistical Mechanics And Its Applications. Amsterdam: Elsevier Science Bv, v. 456, p. 145-156, 2016.
dc.identifier.doi10.1016/j.physa.2016.03.019
dc.identifier.fileWOS000376693500015.pdf
dc.identifier.issn0378-4371
dc.identifier.lattes8232289412108723
dc.identifier.orcid0000-0002-2080-8053
dc.identifier.urihttp://hdl.handle.net/11449/161543
dc.identifier.wosWOS:000376693500015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhysica A-statistical Mechanics And Its Applications
dc.relation.ispartofsjr0,773
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMathematical oncology
dc.subjectCancer
dc.subjectTumor-induced angiogenesis
dc.subjectChemotherapy
dc.titleEvaluating the efficacies of Maximum Tolerated Dose and metronomic chemotherapies: A mathematical approachen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes8232289412108723[3]
unesp.author.orcid0000-0002-2080-8053[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentBioestatística - IBBpt

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