A Critical Review of Biological Properties, Delivery Systems and Analytical/Bioanalytical Methods for Determination of Bevacizumab

dc.contributor.authorFilippo, Leonardo Delello Di [UNESP]
dc.contributor.authordos Santos, Karen Cristina [UNESP]
dc.contributor.authorHanck-Silva, Gilmar [UNESP]
dc.contributor.authorde Lima, Felipe Tita [UNESP]
dc.contributor.authorGremião, Maria Palmira Daflon [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T02:39:35Z
dc.date.available2020-12-12T02:39:35Z
dc.date.issued2020-01-01
dc.description.abstractBevacizumab is a chimeric monoclonal human-murine antibody originated from murine monoclonal antibody (muMAb A4.6.1) with the human immunoglobulin IgG1. BVZ binds the extracellular portion of vascular endothelial growth factor receptors (VEGFR), which have tyrosine kinase activity. The mechanism of action of BVZ involves binding to VEGFR, Flt-1 (VEGFR-1) and KDR/Flk-1 (VEGFR-2), inducing homodimerization of two receptor subunits, and, consequently, autophosphorylation of their tyrosine kinase domains located inside the cytoplasm. With the advent of nanostructured systems it is increasingly necessary to look for safe analytical methods, ensuring the reliability of the results obtained by them, becoming essential to ensure the quality of medicines. In this work, the incorporation of bevacizumab in to different drug delivery systems was presented. Moreover, detailed investigation was performed about methods for qualitative and quantitative analyses of bevacizumab, including, biological fluids, and drug delivery systems, were investigated. Most recently high performance liquid chromatography coupled with various detectors, liquid chromatography, mass spectrometry and ELISA were used for this purpose. Thus, this review was performed to evaluate the benefits of bevacizumab carried by nanostructured systems and the analytical methods available for detection and quantification of these drugs.en
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1080/10408347.2020.1743641
dc.identifier.citationCritical Reviews in Analytical Chemistry.
dc.identifier.doi10.1080/10408347.2020.1743641
dc.identifier.issn1547-6510
dc.identifier.issn1040-8347
dc.identifier.scopus2-s2.0-85083644238
dc.identifier.urihttp://hdl.handle.net/11449/201703
dc.language.isoeng
dc.relation.ispartofCritical Reviews in Analytical Chemistry
dc.sourceScopus
dc.subjectAnalytical methods
dc.subjectbevacizumab
dc.subjectdelivery systems
dc.titleA Critical Review of Biological Properties, Delivery Systems and Analytical/Bioanalytical Methods for Determination of Bevacizumaben
dc.typeResenha
unesp.author.orcid0000-0003-0975-7280[4]
unesp.author.orcid0000-0002-6698-0545[6]
unesp.departmentFármacos e Medicamentos - FCFpt

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