Isolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii

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dc.contributor.authorDa Graça Sgarbi, Diana Bridon
dc.contributor.authorDa Silva, Antonio Jorge Ribeiro
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.contributor.authorSilva, Célio Lopes
dc.contributor.authorAngluster, Jayme
dc.contributor.authorAlviano, Celuta Sales
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionCidade Universitária
dc.date.accessioned2014-05-27T11:18:17Z
dc.date.available2014-05-27T11:18:17Z
dc.date.issued1997-12-01
dc.description.abstractErgosterol peroxide, a presumed product of the H2O2-dependent enzymatic oxidation of ergosterol, has been isolated from yeast from yeast forms of the pathogenic fungus Sporothrix schenckii. The substance, which may have a role in fungal virulence, has been characterized mainly using spectroscopic methods (1H and 13C nuclear magnetic resonance and high resolution mass spectra). The purified compound showed a molecular formula of C28H44O3, displaying characteristic features of epidioxy sterols and was reverted to ergosterol when submitted to S. schenckii enzymatic extract.en
dc.description.affiliationDepto. de Microbiol. e Parasitologia Instituto Biomédico Universidade Federal Fluminense, Niterói, RJ
dc.description.affiliationNucleo de Pesq. em Produtos Naturais Univ. Federal do Rio de Janeiro, RJ
dc.description.affiliationDepto. de Análises Clinicas Faculdade Cie. Farmaceuticas A. Univ. Paulista Julio Mesquita Filho, Araraquara, SP
dc.description.affiliationDepto. Parasitol., Microbiol. I. Esc. de Med. de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, SP e
dc.description.affiliationInstituto de Microbiologia Univ. Federal do Rio de Janeiro, RJ
dc.description.affiliationDepartamento de Microbiologia Geral Instituto de Microbiologia Cidade Universitária, Ilha do Fundão 21941-590, Rio de Janeiro, RJ
dc.description.affiliationUnespDepto. de Análises Clinicas Faculdade Cie. Farmaceuticas A. Univ. Paulista Julio Mesquita Filho, Araraquara, SP
dc.format.extent9-14
dc.identifierhttp://dx.doi.org/10.1023/A:1006803832164
dc.identifier.citationMycopathologia, v. 139, n. 1, p. 9-14, 1997.
dc.identifier.doi10.1023/A:1006803832164
dc.identifier.issn0301-486X
dc.identifier.lattes1730146818754269
dc.identifier.scopus2-s2.0-0031413998
dc.identifier.urihttp://hdl.handle.net/11449/65254
dc.identifier.wosWOS:000072341100002
dc.language.isoeng
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectEpidioxy sterol
dc.subjectReactive oxygen species
dc.subjectSporothrix schenckii
dc.subjectantineoplastic agent
dc.subjectdrug derivative
dc.subjectergosterol
dc.subjectergosterol 5,8 peroxide
dc.subjectergosterol-5,8-peroxide
dc.subjectchemistry
dc.subjectisolation and purification
dc.subjectmetabolism
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectSporothrix
dc.subjectthin layer chromatography
dc.subjectAntineoplastic Agents
dc.subjectChromatography, Thin Layer
dc.subjectErgosterol
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectFungi
dc.titleIsolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckiien
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.author.lattes1730146818754269
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR