Correlation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extract

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dc.contributor.authorde Freitas Araujo, Marcelo Gonzaga [UNESP]
dc.contributor.authorHilario, Felipe [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorSantos, Lourdes Campaner dos [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorSotomayor, Claudia Elena
dc.contributor.authorBauab, Tais Maria [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidad Nacional de Córdoba
dc.date.accessioned2014-05-20T14:21:08Z
dc.date.available2014-05-20T14:21:08Z
dc.date.issued2012-07-01
dc.description.abstractThe biological activities of a plant extract depend on a complex sum of individual properties including the antioxidant activity. Several biological activities protect against the harmful action of reactive oxygen species (ROS), and here we focused our attention on the relationship between the biological activities tested and the antioxidant properties. In this study, the total flavonoid content as well as the antioxidant, antimicrobial, hemolytic and cytotoxicity activities of the methanolic extract of Leitothrix spiralis leaves were evaluated. The extract showed a total flavonoid content of 19.26% and the chemical characterization by HPLC-PAD confirmed the presence of flavonoids as the major secondary metabolite compounds. Significant antioxidant activity (IC50 = 1.743 mu g/mL +/- 0.063) was demonstrated and was effective against Gram-negative organisms and all Candida strains tested, and showed an ability to inhibit hyphal formation. Non-hemolytic and antiproliferative activity could be demonstrated.en
dc.description.affiliationSão Paulo State Univ UNESP, Dept Biol Sci, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Clin Anal Dept, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationNatl Univ Cordoba, Dept Clin Biochem, CIBICI CONICET, Fac Chem Sci, RA-5000 Cordoba, Argentina
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Biol Sci, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Clin Anal Dept, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
dc.format.extent9260-9277
dc.identifierhttp://dx.doi.org/10.3390/ijms13079260
dc.identifier.citationInternational Journal of Molecular Sciences. Basel: Mdpi Ag, v. 13, n. 7, p. 9260-9277, 2012.
dc.identifier.doi10.3390/ijms13079260
dc.identifier.fileWOS000306760000042.pdf
dc.identifier.issn1661-6596
dc.identifier.lattes3538253640602977
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/26322
dc.identifier.wosWOS:000306760000042
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectLeiothrix spiralisen
dc.subjectluteolinen
dc.subjectantioxidanten
dc.subjectantimicrobialen
dc.subjecthemolyticen
dc.subjectcitotoxicityen
dc.titleCorrelation among Antioxidant, Antimicrobial, Hemolytic, and Antiproliferative Properties of Leiothrix spiralis Leaves Extracten
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMdpi Ag
unesp.author.lattes3538253640602977
unesp.author.orcid0000-0003-3032-2556[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Ciências Biológicas - FCFAR
Artigos - Análises Clínicas - FCFAR
Artigos - Química Orgânica - IQ