Hippocampal insulin signaling and neuroprotection mediated by physical exercise in Alzheimer´s Disease
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Data
2017
Autores
Kuga, Gabriel Keine
Botezelli, José Diego
Gaspar, Rafael Calais
Gomes, Ricardo José
Pauli, José Rodrigo
Leme, José Alexandre Curiacos De Almeida
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista
Resumo
Abstract Epidemiological studies indicate continuous increases in the prevalence of Alzheimer’s Disease (AD) in the next few decades. The key feature of this disease is hippocampal neurodegeneration. This structure has an important role in learning and memory. Intense research efforts have sought to elucidate neuroprotective mechanisms responsible for hippocampal integrity. Insulin signaling seems to be a very promising pathway for the prevention and treatment of AD. This hormone has been described as a powerful activator of neuronal survival. Recent research showed that reduced insulin sensitivity leads to low-grade inflammation, and both phenomena are closely related to AD genesis. Concomitantly, exercise has been shown to exert anti-inflammatory effects and to promote improvement in insulin signaling in the hippocampus, which supports neuronal survival and constitutes an interesting non-pharmacological alternative for the prevention and treatment of AD. This review examines recent advances in understanding the molecular mechanisms involved in hippocampal neuroprotection mediated by exercise.
Descrição
Palavras-chave
insulin, hippocampus, inflammation, physical exercise
Como citar
Motriz: Revista de Educação Física. Universidade Estadual Paulista, v. 23, n. spe, p. -, 2017.