Focus on Vitamin D, Inflammation and Type 2 Diabetes

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dc.contributor.authorAndrade Chagas, Carlos Eduardo [UNESP]
dc.contributor.authorBorges, Maria Carolina
dc.contributor.authorMartini, Lgia Araujo
dc.contributor.authorRogero, Marcelo Macedo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:48:55Z
dc.date.available2014-05-20T13:48:55Z
dc.date.issued2012-01-01
dc.description.abstractThe initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes.en
dc.description.affiliationUniv São Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Inst Biosci, Dept Educ, Ctr Nutr Practice & Res, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Inst Biosci, Dept Educ, Ctr Nutr Practice & Res, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 09/54395-0
dc.description.sponsorshipIdFAPESP: 10/08386-7
dc.format.extent52-67
dc.identifierhttp://dx.doi.org/10.3390/nu4010052
dc.identifier.citationNutrients. Basel: Mdpi Ag, v. 4, n. 1, p. 52-67, 2012.
dc.identifier.doi10.3390/nu4010052
dc.identifier.fileWOS000300718000005.pdf
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11449/17410
dc.identifier.wosWOS:000300718000005
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofNutrients
dc.relation.ispartofjcr4.196
dc.relation.ispartofsjr1,557
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectvitamin Den
dc.subjectinflammationen
dc.subjectdiabetesen
dc.titleFocus on Vitamin D, Inflammation and Type 2 Diabetesen
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMdpi Ag
unesp.author.orcid0000-0001-7785-4547[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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