Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats

dc.contributor.authorMissassi, Gabriela [UNESP]
dc.contributor.authorDos Santos Borges, Cibele [UNESP]
dc.contributor.authorDe Lima Rosa, Josiane [UNESP]
dc.contributor.authorVillelae Silva, Patrícia [UNESP]
dc.contributor.authorDa Cunha Martins, Airton
dc.contributor.authorBarbosa, Fernando
dc.contributor.authorDe Grava Kempinas, Wilma [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:23:59Z
dc.date.available2018-12-11T17:23:59Z
dc.date.issued2017-01-01
dc.description.abstractOxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.en
dc.description.affiliationDepartment of Morphology Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationGraduate Program in Cell and Structural Biology University of Campinas (UNICAMP)
dc.description.affiliationDepartment of Clinical Analyses Toxicology and Food Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1155/2017/2172981
dc.identifier.citationOxidative Medicine and Cellular Longevity, v. 2017.
dc.identifier.doi10.1155/2017/2172981
dc.identifier.file2-s2.0-85042589513.pdf
dc.identifier.issn1942-0994
dc.identifier.issn1942-0900
dc.identifier.scopus2-s2.0-85042589513
dc.identifier.urihttp://hdl.handle.net/11449/177099
dc.language.isoeng
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.relation.ispartofsjr1,558
dc.relation.ispartofsjr1,558
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleChrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Ratsen
dc.typeArtigo
unesp.author.orcid0000-0001-8686-144X[1]
unesp.author.orcid0000-0003-3711-811X[2]
unesp.author.orcid0000-0002-5271-3825[3]
unesp.author.orcid0000-0001-9233-2413[4]
unesp.author.orcid0000-0002-2498-0619[6]
unesp.author.orcid0000-0002-2112-5123[7]
unesp.departmentAlimentos e Nutrição - FCFpt

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