Mutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepa

Página do item simplificado
dc.contributor.authorFelicidade, I. [UNESP]
dc.contributor.authorLima, J. D.
dc.contributor.authorPesarini, J. R.
dc.contributor.authorMonreal, A. C. D.
dc.contributor.authorMantovani, M. S.
dc.contributor.authorRibeiro, L. R. [UNESP]
dc.contributor.authorOliveira, R. J.
dc.contributor.institutionCentro Universitário Filadélfia (UNIFIL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2015-11-03T15:27:44Z
dc.date.available2015-11-03T15:27:44Z
dc.date.issued2014-01-01
dc.description.abstractPolyphenolic compounds present in rosemary were found to have antioxidant properties, anticarcinogenic activity, and to increase the detoxification of pro-carcinogens. The aim of the study was to determine the effect the aqueous extract of rosemary (AER) on mutagenicity induced by methylmethane sulfonate in meristematic cells of Allium cepa, as well as to describe its mode of action. Anti-mutagenicity experiments were carried out with 3 different concentrations of AER, which alone showed no mutagenic effects. In antimutagenicity experiments, AER showed chemopreventive activity in cultured meristematic cells of A. cepa against exposure to methylmethane sulfonate. Additionally, post-treatment and simultaneous treatment using pre-incubation protocols were the most effective. Evaluation of different protocols and the percent reduction in DNA indicated bioantimutagenic as well desmutagenic modes of action for AER. AER may be chemopreventive and antimutagenic.en
dc.description.affiliationCentro de Estudos em Nutrição e Genética Toxicológica, Centro Universitário Filadélfia, Londrina, PR, Brasil
dc.description.affiliationCentro de Estudos em Célula Tronco, Terapia Celular e Genética Toxicológica, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil
dc.description.affiliationPrograma de Pós-Graduação e Saúde em Desenvolvimento na Região Centro-Oeste, Faculdade de Medicina “Dr. Hélio Mandetta”, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil
dc.description.affiliationCentro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil
dc.description.affiliationDepartamento de Biologia Geral, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, Brasil
dc.description.affiliationPrograma de Mestrado em Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
dc.description.affiliationUnespPrograma de Pós-Graduação em Patologia, Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brasil
dc.description.affiliationUnespPrograma de Pós-Graduação em Biologia Celular e Molecular, Universidade Estadual Paulista, Rio Claro, SP, Brasil.
dc.description.sponsorshipCentro Universitário Filadélfia (UNIFIL)
dc.format.extent9986-9996
dc.identifierhttp://www.geneticsmr.com/articles/3767
dc.identifier.citationGenetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 13, n. 4, p. 9986-9996, 2014.
dc.identifier.doi10.4238/2014.November.28.3
dc.identifier.issn1676-5680
dc.identifier.urihttp://hdl.handle.net/11449/129911
dc.identifier.wosWOS:000350229200031
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics And Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAntimutagenicityen
dc.subjectAqueous extracten
dc.subjectChemoprevention DNA damageen
dc.subjectMethylmethane sulfonateen
dc.titleMutagenic and antimutagenic effects of aqueous extract of rosemary (Rosmarinus officinalis L.) on meristematic cells of Allium cepaen
dc.typeArtigo
dcterms.rightsHolderFunpec-editora
unesp.author.orcid0000-0001-8981-2440[1]
unesp.author.orcid0000-0001-5268-6508[5]
unesp.author.orcid0000-0002-0840-7193[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Coleções

Artigos - Patologia - FMB
Artigos - Biologia - IBRC