Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate

Fontanari, Gustavo Guadagnucci [UNESP]; Batistuti, José Paschoal [UNESP]; da Cruz, Robison Jose; Nascimento Saldiva, Paulo Hilario; Gomes Areas, Jose Alfredo

Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate

Arquivos

WOS000301022400055.pdf (447.99 KB)

Data

2012-06-01

Autores

Fontanari, Gustavo Guadagnucci

Batistuti, José Paschoal

da Cruz, Robison Jose

Nascimento Saldiva, Paulo Hilario

Gomes Areas, Jose Alfredo

Editor

Elsevier B.V.

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

This study describes the hypocholesterolaemic effect of whole lupin and its protein in hamsters. The diets were: casein (control group HC), lupin protein isolate (group HPI) and whole lupin seed (group HWS). Diets from HPI and HWS promoted a significant reduction of total cholesterol and non-HDL cholesterol in the hamsters' plasma as compared with HC. The true digestibility of HPI and HC groups were similar and differed significantly from the HWS one, which in turn showed a significant difference in total sterol excretion as compared to the former groups. Histological analysis of the liver revealed that animals fed on HPI and HWS diets presented a low level of steatosis (level 1) as compared to the ones fed on HC diet (level 4). Our findings demonstrate that protein isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism and a protector effect on development of hepatic steatosis. (C) 2011 Elsevier Ltd. All rights reserved.