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Cholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolate

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dc.contributor.authorFontanari, Gustavo Guadagnucci [UNESP]
dc.contributor.authorBatistuti, José Paschoal [UNESP]
dc.contributor.authorda Cruz, Robison Jose
dc.contributor.authorNascimento Saldiva, Paulo Hilario
dc.contributor.authorGomes Areas, Jose Alfredo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:44Z
dc.date.available2014-05-20T13:23:44Z
dc.date.issued2012-06-01
dc.description.abstractThis study describes the hypocholesterolaemic effect of whole lupin and its protein in hamsters. The diets were: casein (control group HC), lupin protein isolate (group HPI) and whole lupin seed (group HWS). Diets from HPI and HWS promoted a significant reduction of total cholesterol and non-HDL cholesterol in the hamsters' plasma as compared with HC. The true digestibility of HPI and HC groups were similar and differed significantly from the HWS one, which in turn showed a significant difference in total sterol excretion as compared to the former groups. Histological analysis of the liver revealed that animals fed on HPI and HWS diets presented a low level of steatosis (level 1) as compared to the ones fed on HC diet (level 4). Our findings demonstrate that protein isolate from Lupinus albus from Brazil has a metabolic effect on endogenous cholesterol metabolism and a protector effect on development of hepatic steatosis. (C) 2011 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Fac Saúde Publ, Dept Nutr, BR-01246904 São Paulo, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Alimentos & Nutr, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Ctr Bioterismo, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Patol, BR-01246903 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Alimentos & Nutr, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipPredilecta Foods (Sao Lourenco do Turvo, SP, Brazil)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.format.extent1521-1526
dc.identifierhttp://dx.doi.org/10.1016/j.foodchem.2011.11.145
dc.identifier.citationFood Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1521-1526, 2012.
dc.identifier.doi10.1016/j.foodchem.2011.11.145
dc.identifier.fileWOS000301022400055.pdf
dc.identifier.issn0308-8146
dc.identifier.lattes6406973152069497
dc.identifier.urihttp://hdl.handle.net/11449/7212
dc.identifier.wosWOS:000301022400055
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood Chemistry
dc.relation.ispartofjcr4.946
dc.relation.ispartofsjr1,793
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectLupinus albusen
dc.subjectProtein isolateen
dc.subjectCholesterolen
dc.subjectHypocholesterolemiaen
dc.subjectSteatosisen
dc.subjectHamstersen
dc.titleCholesterol-lowering effect of whole lupin (Lupinus albus) seed and its protein isolateen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes6406973152069497
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAlimentos e Nutrição - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas