Efeito da exposição à fumaça de cigarro durante a prenhez e a lactação de ratas e sua prole sobre parâmetros séricos e morfométricos

dc.contributor.authorGomes, Patrícia Rodrigues Lourenço [UNESP]
dc.contributor.authorSeraphim, Patricia Monteiro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:25:21Z
dc.date.available2014-05-27T11:25:21Z
dc.date.issued2010-12-01
dc.description.abstractPURPOSE: to investigate the effect of cigarette smoke exposure on body and tissue weight gain, serum parameters and milk yield during pregnancy and lactation in rats, and the impact on offspring from birth toil young adulthood. METHODS: 40 Wistar pregnant rats were randomly divided into: CG - not exposed to cigarette smoke and sacrificed at the end of pregnancy; CL - not exposed to cigarette smoke and sacrificed at the end of lactation; FG - exposed to cigarette smoke and sacrificed at the end of pregnancy; FL - exposed to cigarette smoke and sacrificed at the end of lactation. The offspring were separated by gender and divided according to their mothers' groups. Tissue weight, body weight and serum parameters were evaluated in rats and offspring. Milk yield per pup was calculated. RESULTS: body weight was decreased in FL during lactation (CL=267.0±7.2; FL=235.5±7.2 g*, *p<0.05). Adipose tissue was not detected in the CL and FL groups, and was reduced in FG compared to CG (CG=3.3±0.3; FG=2.4±0.3 g*, *p<0.05). Rats exposed to cigarette smoke had higher blood glucose levels (CG=113±17, CL=86±16, FG=177±21*, FL=178±23 mg/dL*, *p<0.05 CG versus FG e CL versus FL), CL and FL groups presented lower HDL-cholesterol with no change in total cholesterol. Finally, rats exposed to cigarette smoke had lower milk yield compared to unexposed rats (CL=6.7±0.4, FL=5.4±0.3 g*, *p<0.05). In offspring from the FG and FL groups, there was a decrease of body weight from birth to young adulthood, with no changes in gastrocnemius, liver or heart weights in any group, and adipose tissue was no detected in female offspring. There was an increase in blood glucose in offspring of both sexes from rats exposed to cigarette smoke (males: Pcg=107±10.5, Pcl=115±8.6, Pfg=148±16.8*, Pfl=172±11.2**; females: Pcg=109±27.2, Pcl=104±9.7, Pfg=134±20.0*, Pfl=126±13.3**; p<0.05 *Pcg versus Pfg and **Pcl versus Pfl). CONCLUSIONS: exposure to cigarette smoke provokes impairment of morphometric and serum parameters during pregnancy and lactation both in mothers and offspring, which is maintained during young adulthood.en
dc.description.affiliationFisioterapia pela Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista UNESP, Presidente Prudente (SP)
dc.description.affiliationDepartamento de Fisioterapia da Faculdade de Ciências e Tecnologia da Universidade Estadual UNESP, Presidente Prudente (SP)
dc.description.affiliationUnespFisioterapia pela Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista UNESP, Presidente Prudente (SP)
dc.description.affiliationUnespDepartamento de Fisioterapia da Faculdade de Ciências e Tecnologia da Universidade Estadual UNESP, Presidente Prudente (SP)
dc.format.extent591-596
dc.identifierhttp://dx.doi.org/10.1590/S0100-72032010001200005
dc.identifier.citationRevista Brasileira de Ginecologia e Obstetricia, v. 32, n. 12, p. 591-596, 2010.
dc.identifier.doi10.1590/S0100-72032010001200005
dc.identifier.file2-s2.0-79955082381.pdf
dc.identifier.issn0100-7203
dc.identifier.lattes0411008599070871
dc.identifier.orcid0000-0003-2145-6640
dc.identifier.scieloS0100-72032010001200005
dc.identifier.scopus2-s2.0-79955082381
dc.identifier.urihttp://hdl.handle.net/11449/72076
dc.language.isopor
dc.relation.ispartofRevista Brasileira de Ginecologia e Obstetrícia
dc.relation.ispartofsjr0,292
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnimal Lactation Animals
dc.subjectNewborn Homeostasis
dc.subjectSmoking/adverse effects Pregnancy
dc.subjectanimal
dc.subjectdrug effect
dc.subjectenvironmental exposure
dc.subjectfemale
dc.subjectgrowth, development and aging
dc.subjectlactation
dc.subjectpassive smoking
dc.subjectpregnancy
dc.subjectprenatal exposure
dc.subjectrat
dc.subjectsuckling
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectAnimals, Suckling
dc.subjectFemale
dc.subjectLactation
dc.subjectMaternal Exposure
dc.subjectPregnancy
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTobacco Smoke Pollution
dc.titleEfeito da exposição à fumaça de cigarro durante a prenhez e a lactação de ratas e sua prole sobre parâmetros séricos e morfométricospt
dc.title.alternativeEffect of cigarette smoke exposure during pregnancy and lactation of rats and the offspring on the serum and morphometric parametersen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rbgo/paboutj.htm#3
unesp.author.lattes0411008599070871[2]
unesp.author.orcid0000-0003-2145-6640[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept

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