Müller cells and diabetic retinopathy.

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dc.contributor.authorSchellini, Silvana Artioli [UNESP]
dc.contributor.authorGregório, E. A.
dc.contributor.authorSpadella, César Tadeu [UNESP]
dc.contributor.authorMachado, J. L.
dc.contributor.authorde-Moraes-Silva, M. A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:01Z
dc.date.available2014-05-27T11:18:01Z
dc.date.issued1995-09-01
dc.description.abstractMüller cells provide nutrition for neural cells. We studied the structure and ultrastructure of Müller cells in the retina of thirty 3-month old Wistar rats, divided equally into 3 groups: normal rats, alloxan diabetic rats and treated alloxan diabetic rats, 1 and 12 months after induction of diabetes. We observed that the Müller cell nuclei under light microscope examination had hexagonal shape and higher density than the other nuclei. Differences between groups could be observed only by electron microscopy. In the diabetic rats, Müller cells presented dispersion of nuclear chromatin and electrondense nuclear granulations, with the presence of increased glycogen, dense bodies and lysosomes in the cytoplasm. The alterations were more frequent in the perivascular region and at 12 months. The treated diabetic rats exhibited some alterations we observed in diabetic rats, but these alterations were less intense. We conclude that, despite the treatment, the diabetic retinopathy continues to evolve.en
dc.format.extent977-980
dc.identifier.citationBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], v. 28, n. 9, p. 977-980, 1995.
dc.identifier.issn0100-879X
dc.identifier.lattes9420249100835492
dc.identifier.lattes6223012281302736
dc.identifier.scopus2-s2.0-0029366843
dc.identifier.urihttp://hdl.handle.net/11449/64637
dc.language.isoeng
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectanimal
dc.subjectdiabetic retinopathy
dc.subjectexperimental diabetes mellitus
dc.subjectglia
dc.subjectpathology
dc.subjectrat
dc.subjectretina
dc.subjectultrastructure
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetic Retinopathy
dc.subjectNeuroglia
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectRetina
dc.titleMüller cells and diabetic retinopathy.en
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm#Copyright
unesp.author.lattes9420249100835492
unesp.author.lattes6223012281302736
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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