Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial

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dc.contributor.authorBenjamim, Cicero Jonas R.
dc.contributor.authorSousa, Yaritza Brito Alves
dc.contributor.authorPorto, Andrey Alves [UNESP]
dc.contributor.authorde Moraes Pontes, Yasmim Mota
dc.contributor.authorTavares, Simone Sakagute
dc.contributor.authorda Silva Rodrigues, Guilherme
dc.contributor.authorda Silva, Leonardo Santos Lopes
dc.contributor.authorda Silva Goncalves, Leonardo
dc.contributor.authorGuimaraes, Carolina Scoqui
dc.contributor.authorRebelo, Macário Arosti
dc.contributor.authorda Silva Sobrinho, Andressa Crystine
dc.contributor.authorTanus-Santos, Jose E.
dc.contributor.authorValenti, Vitor Engracia [UNESP]
dc.contributor.authorGualano, Bruno
dc.contributor.authorBueno Júnior, Carlos Roberto
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2023-07-29T14:00:40Z
dc.date.available2023-07-29T14:00:40Z
dc.date.issued2023-12-01
dc.description.abstractBackground: There is no evidence of the use of beetroot juice with a previously recommended dose of nitrate (NO3) (> 300 mg) on the cardiovascular performance during and recovery following exercise in postmenopausal women with systemic arterial hypertension (SAH). Methods: We will investigate the effects of beetroot juice rich in NO3 acutely (800 mg) and during a week with daily doses (400 mg) on blood pressure, heart rate (HR), cardiac autonomic control, endothelial function, inflammatory, hormonal, and stress biomarkers oxidative stress and enzymes involved in nitric oxide synthesis and mitochondrial regulation, under resting conditions, as well as mediated by submaximal aerobic exercise sessions. Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 25 physically inactive women with SAH will undergo an acute and 1-week trial, each with two intervention protocols: (1) placebo and (2) beetroot, in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval. On collection days, exercise will be performed on a treadmill for 40 min at a speed corresponding to 65–70% of VO2peak. The collection of variables (cardiovascular, autonomic, and blood samples for molecular analyses) of the study will take place at rest (135 min after ingestion of the intervention), during exercise (40 min), and in the effort recovery stage (during 60 min) based on previously validated protocols. The collections were arranged so that the measurement of one variable does not interfere with the other and that they have adequate intervals between them. Discussion: The results of this research may help in the real understanding of the nutritional compounds capable of generating safety to the cardiovascular system during physical exercise, especially for women who are aging and who have cardiovascular limitations (e.g., arterial hypertension) to perform physical exercise. Therefore, our results will be able to help specific nutritional recommendations to optimize cardiovascular health. Trial registration: ClinicalTrials.gov NCT05384340. Registered on May 20, 2022.en
dc.description.affiliationDepartment of Internal Medicine Ribeirão Preto Medical School University of São Paulo, SP
dc.description.affiliationRibeirao Preto Nursing School University of São Paulo, SP
dc.description.affiliationMovement Sciences Autonomic Nervous System Center (CESNA) São Paulo State University (UNESP), SP
dc.description.affiliationRibeirao Preto School of Physical Education and Sports University of São Paulo, SP
dc.description.affiliationDepartment of Pharmacology Faculty of Medical Sciences State University of Campinas, SP
dc.description.affiliationDepartment of Pharmacology Ribeirão Preto Medical School University of São Paulo, SP
dc.description.affiliationAutonomic Nervous System Center (CESNA) São Paulo State University (UNESP), SP
dc.description.affiliationApplied Physiology & Nutrition Research Group University of São Paulo Medical School (FMUSP), SP
dc.description.affiliationUnespMovement Sciences Autonomic Nervous System Center (CESNA) São Paulo State University (UNESP), SP
dc.description.affiliationUnespAutonomic Nervous System Center (CESNA) São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.1186/s13063-023-07117-2
dc.identifier.citationTrials, v. 24, n. 1, 2023.
dc.identifier.doi10.1186/s13063-023-07117-2
dc.identifier.issn1745-6215
dc.identifier.scopus2-s2.0-85147633464
dc.identifier.urihttp://hdl.handle.net/11449/249035
dc.language.isoeng
dc.relation.ispartofTrials
dc.sourceScopus
dc.subjectBeta vulgaris
dc.subjectCardiovascular physiological phenomena
dc.subjectHypertension
dc.subjectNitrate
dc.subjectPost-menopause
dc.subjectSports nutritional sciences
dc.titleNitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trialen
dc.typeArtigo
unesp.author.orcid0000-0002-8679-7166[1]

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