Propolis effect on streptozotocin-induced diabetic rats

dc.contributor.authorSartori, D. R. S. [UNESP]
dc.contributor.authorKawakami, C. L. [UNESP]
dc.contributor.authorOrsatti, C. L. [UNESP]
dc.contributor.authorSforcin, J. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:54Z
dc.date.available2014-05-20T13:49:54Z
dc.date.issued2009-01-01
dc.description.abstractPropolis is one of the hive products that has been used extensively in folk medicine, due to its several biological and pharmacological properties. Besides, propolis-containing products have been intensely marketed by the pharmaceutical industry and health-food stores. This work was carried out in order to investigate whether propolis treatment could revert the metabolic alterations of streptozotocin-induced diabetic rats. Animals were kept in metabolic cages and diabetes was induced by a single dose of streptozotocin (35 mg/kg, IV). After a week, rats with glycemia higher than 230 mg/dL were divided into two groups and treated with ethanolic extract of propolis (10 and 90 mg/kg, PO) for seven days. Glycemia and free fatty acids were determined, as well as food and water intake, body weight and urine volume were registered weekly. Data showed no significant differences in the analyzed variables. Based on these results, one may conclude that propolis had no effects after diabetes establishment, in our conditions assays. Further assays with different concentrations of propolis and periods of administration should be carried out in order to evaluate its therapeutic potential in this disease.en
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Biosci Inst, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Biosci Inst, Dept Physiol, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Biosci Inst, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Biosci Inst, Dept Physiol, Botucatu, SP, Brazil
dc.format.extent93-102
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992009000100009
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 15, n. 1, p. 93-102, 2009.
dc.identifier.fileS1678-91992009000100009.pdf
dc.identifier.issn1678-9199
dc.identifier.lattes5272388662903892
dc.identifier.scieloS1678-91992009000100009
dc.identifier.urihttp://hdl.handle.net/11449/17798
dc.identifier.wosWOS:000264366500009
dc.language.isoeng
dc.publisherUniversidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBrazilian propolisen
dc.subjectdiabetesen
dc.subjectglucoseen
dc.subjectfree fatty acidsen
dc.titlePropolis effect on streptozotocin-induced diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
dcterms.rightsHolderCevap-unesp
unesp.author.lattes5272388662903892
unesp.author.orcid0000-0001-9161-5737[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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