Microencapsulated sodium butyrate on the intestinal integrity of broilers challenged with Eimeria spp.

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dc.contributor.authorLima, Gabrieli Andressa de [UNESP]
dc.contributor.authorBarbosa, Bárbara Fernanda da Silva [UNESP]
dc.contributor.authorVentura, Gabriela [UNESP]
dc.contributor.authorGonçalves, Izabela Mlaker [UNESP]
dc.contributor.authorCosta, Vladimir Eliodoro [UNESP]
dc.contributor.authorPolycarpo, Gustavo do Valle [UNESP]
dc.contributor.authorMadeira, Alda Maria Backx Noronha
dc.contributor.authorCruz-Polycarpo, Valquíria Cação [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T16:09:59Z
dc.date.available2023-07-29T16:09:59Z
dc.date.issued2023-04-01
dc.description.abstractTo explore the effect of microencapsulated sodium butyrate (MSB) on the performance, intestinal morphometry, intestinal goblet cell count, cellular turnover of the intestinal mucosa, oocyst count per gram of feces (OPG), and small intestine lesion score of broilers challenged with Eimeria spp., 1,200 Ross® male broiler chicks were distributed in a completely randomized design, with five treatments and six replications, and reared for 42 days. At 16 D-old, the birds were inoculated orally with 0.5 ml of a solution containing an Eimeria spp. pool and the treatments consisted of NC: negative control, basal diet (BD); 1,000 MSB: BD + 1,000 mg/kg MSB; 1,500 MSB: BD + 1,500 mg/kg MSB; 2,000 MSB: BD + 2,000 mg/kg MSB; PC: positive control, BD + avilamycin. No statistical differences were observed for the variables performance, intestinal morphometry or intestinal goblet cell count during the experiment. In the OPG and lesion score, a difference was observed only for periods of collection, in which greater excretion was detected seven days post-inoculation. The lesions caused by E. acervulina and E. tenella were attenuated 10- and 8-days post-inoculation, respectively and the largest lesions caused by E. maxima were observed five days post-inoculation. In the period 0–21 days, the treatments receiving MSB or antibiotic presented greater cellular turnover of the intestinal mucosa. In the period 22–42 days, the treatments with inclusion of 1,500 mg/kg MSB and 2,000 mg/kg MSB and PC showed lower cell turnover of the intestinal mucosa, indicating that MSB was able to protect the intestinal mucosa. It is concluded based turnover results that MSB benefits the intestinal development in the starter phase, and it is similar to the antibiotic in terms of preservation of the post-challenge intestinal mucosa.en
dc.description.affiliationSão Paulo State University (Unesp) College of Technology and Agricultural Sciences Department of Animal Science, São Paulo
dc.description.affiliationSão Paulo State University (Unesp) Institute of Biosciences Environmental Stable Isotopes Center, São Paulo
dc.description.affiliationUniversity of São Paulo (Usp) Institute of Biomedical Sciences Department of Parasitology, São Paulo
dc.description.affiliationUnespSão Paulo State University (Unesp) College of Technology and Agricultural Sciences Department of Animal Science, São Paulo
dc.description.affiliationUnespSão Paulo State University (Unesp) Institute of Biosciences Environmental Stable Isotopes Center, São Paulo
dc.identifierhttp://dx.doi.org/10.1016/j.livsci.2023.105209
dc.identifier.citationLivestock Science, v. 270.
dc.identifier.doi10.1016/j.livsci.2023.105209
dc.identifier.issn1871-1413
dc.identifier.scopus2-s2.0-85151466643
dc.identifier.urihttp://hdl.handle.net/11449/249815
dc.language.isoeng
dc.relation.ispartofLivestock Science
dc.sourceScopus
dc.subjectButyric acid
dc.subjectIntestinal morphology
dc.subjectIntestinal turnover
dc.subjectMicroencapsulation
dc.subjectStable isotopes
dc.titleMicroencapsulated sodium butyrate on the intestinal integrity of broilers challenged with Eimeria spp.en
dc.typeArtigo
unesp.author.orcid0000-0003-2719-0425[1]
unesp.departmentZootecnia - FCATpt

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Dracena - FCAT - Faculdade de Ciências Agrárias e Tecnológicas