An inhalable powder formulation based on micro-and nanoparticles containing 5-fluorouracil for the treatment of metastatic melanoma
dc.contributor.author | Zatta, Kelly Cristine | |
dc.contributor.author | Frank, Luiza A. | |
dc.contributor.author | Reolon, Luciano Antonio | |
dc.contributor.author | Amaral-Machado, Lucas | |
dc.contributor.author | Egito, Eryvaldo S. T. | |
dc.contributor.author | Gremião, Maria Palmira Daflon [UNESP] | |
dc.contributor.author | Pohlmann, Adriana Raffin | |
dc.contributor.author | Guterres, Silvia S. | |
dc.contributor.institution | Universidade Federal do Rio Grande do Sul (UFRGS) | |
dc.contributor.institution | Centro Universitário Ritter dos Reis–UniRitter | |
dc.contributor.institution | Universidade Federal do Rio Grande do Norte (UFRN) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2018-12-11T17:35:43Z | |
dc.date.available | 2018-12-11T17:35:43Z | |
dc.date.issued | 2018-02-01 | |
dc.description.abstract | Melanoma is the most aggressive and lethal type of skin cancer, with a poor prognosis because of the potential for metastatic spread. The aim was to develop innovative powder formulations for the treatment of metastatic melanoma based on micro- and nanocarriers containing 5-fluorouracil (5FU) for pulmonary administration, aiming at local and systemic action. Therefore, two innovative inhalable powder formulations were produced by spray-drying using chondroitin sulfate as a structuring polymer: (a) 5FU nanoparticles obtained by piezoelectric atomization (5FU-NS) and (b) 5FU microparticles of the mucoadhesive agent Methocel™ F4M for sustained release produced by conventional spray drying (5FU-MS). The physicochemical and aerodynamic were evaluated in vitro for both systems, proving to be attractive for pulmonary delivery. The theoretical aerodynamic diameters obtained were 0.322 ± 0.07 µm (5FU-NS) and 1.138 ± 0.54 µm (5FU-MS). The fraction of respirable particles (FR%) were 76.84 ± 0.07% (5FU-NS) and 55.01 ± 2.91% (5FU-MS). The in vitro mucoadhesive properties exhibited significant adhesion efficiency in the presence of Methocel™ F4M. 5FU-MS and 5FU-NS were tested for their cytotoxic action on melanoma cancer cells (A2058 and A375) and both showed a cytotoxic effect similar to 5FU pure at concentrations of 4.3 and 1.7-fold lower, respectively. | en |
dc.description.affiliation | Universidade Federal do Rio Grande do Sul (UFRGS) | |
dc.description.affiliation | Escola de Ciências da Saúde Centro Universitário Ritter dos Reis–UniRitter | |
dc.description.affiliation | Universidade Federal do Rio Grande do Norte (UFRN) | |
dc.description.affiliation | Universidade Estadual de São Paulo (UNESP) | |
dc.description.affiliation | Departamento de Química Orgânica Instituto de Química Universidade Federal do Rio Grande do Sul (UFRGS) | |
dc.description.affiliationUnesp | Universidade Estadual de São Paulo (UNESP) | |
dc.identifier | http://dx.doi.org/10.3390/nano8020075 | |
dc.identifier.citation | Nanomaterials, v. 8, n. 2, 2018. | |
dc.identifier.doi | 10.3390/nano8020075 | |
dc.identifier.file | 2-s2.0-85041724369.pdf | |
dc.identifier.issn | 2079-4991 | |
dc.identifier.lattes | 9129780536724256 | |
dc.identifier.scopus | 2-s2.0-85041724369 | |
dc.identifier.uri | http://hdl.handle.net/11449/179573 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nanomaterials | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | 5-fluorouracil | |
dc.subject | Biopolymers | |
dc.subject | Cytotoxicity | |
dc.subject | Metastatic melanoma | |
dc.subject | Microparticles | |
dc.subject | Nanoparticles | |
dc.subject | Pulmonary delivery | |
dc.title | An inhalable powder formulation based on micro-and nanoparticles containing 5-fluorouracil for the treatment of metastatic melanoma | en |
dc.type | Artigo | |
unesp.advisor.lattes | 9129780536724256 | |
unesp.department | Fármacos e Medicamentos - FCF | pt |
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