A soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese mice

dc.contributor.authorde Carvalho Marchesin, Juliana [UNESP]
dc.contributor.authorCeliberto, Larissa Sbaglia [UNESP]
dc.contributor.authorOrlando, Allan Botinhon [UNESP]
dc.contributor.authorde Medeiros, Alexandra Ivo [UNESP]
dc.contributor.authorPinto, Roseli Aparecida [UNESP]
dc.contributor.authorZuanon, José Antônio Sampaio [UNESP]
dc.contributor.authorSpolidorio, Luis Carlos [UNESP]
dc.contributor.authordos Santos, Andrey
dc.contributor.authorTaranto, Maria Pía
dc.contributor.authorCavallini, Daniela Cardoso Umbelino [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionSan Miguel de Tucumán
dc.date.accessioned2018-12-11T17:37:42Z
dc.date.available2018-12-11T17:37:42Z
dc.date.issued2018-09-01
dc.description.abstractThis work investigates the effect of a soy-based probiotic drink (Enterococcus faecium CRL 183 and Bifidobacterium longum ATCC 15707) on the fecal microbiota composition, body weight and inflammatory parameters in diet-induced obese mice. The probiotic group had a lower body weight until 9th week of the study, reduced area and diameter of adipocytes, and showed a significant increase of IL-6 and IL-10 compared to the obesite non-treated group. The intake of a high-fat diet results in an increase of Lactobacillus spp. while the probiotic drink positively modulates the intestinal microbiota by maintaining the population of microorganisms belonging to the phylum Bacteroidetes and increases Bifidobacterium spp. Our study finds that the regular intake of this probiotic drink is able to reduce body weight gain and the size of adipocytes while modulating the fecal microbiota and the immune profile of animals, therefore acting in a beneficial manner in the control of obesity.en
dc.description.affiliationSao Paulo State University (UNESP) School of Pharmaceutical Sciences, Rodovia Araraquara Jaú Km 01 – s/n, Campos Ville
dc.description.affiliationSao Paulo State University (UNESP) School of Dentistry, Rua Humaitá 1680, Centro
dc.description.affiliationCampinas State University (UNICAMP), Cidade Universitária “Zeferino Vaz” 13083-970 Campinas
dc.description.affiliationReference Center for Lactobacilli (CERELA-CONICET) San Miguel de Tucumán
dc.description.affiliationUnespSao Paulo State University (UNESP) School of Pharmaceutical Sciences, Rodovia Araraquara Jaú Km 01 – s/n, Campos Ville
dc.description.affiliationUnespSao Paulo State University (UNESP) School of Dentistry, Rua Humaitá 1680, Centro
dc.format.extent302-313
dc.identifierhttp://dx.doi.org/10.1016/j.jff.2018.07.010
dc.identifier.citationJournal of Functional Foods, v. 48, p. 302-313.
dc.identifier.doi10.1016/j.jff.2018.07.010
dc.identifier.file2-s2.0-85049810414.pdf
dc.identifier.issn1756-4646
dc.identifier.lattes2640929291808415
dc.identifier.scopus2-s2.0-85049810414
dc.identifier.urihttp://hdl.handle.net/11449/180023
dc.language.isoeng
dc.relation.ispartofJournal of Functional Foods
dc.relation.ispartofsjr1,245
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAdipose tissue
dc.subjectCytokine
dc.subjectFasting blood glucose
dc.subjectIntestinal microbiota
dc.subjectObesity
dc.subjectProbiotic
dc.titleA soy-based probiotic drink modulates the microbiota and reduces body weight gain in diet-induced obese miceen
dc.typeArtigo
unesp.author.lattes2640929291808415

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