Effect of physiological overload on pregnancy in women with mitral regurgitation

dc.contributor.authorBorges, Vera Therezinha Medeiros [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorMagalhaes, Claudia G. [UNESP]
dc.contributor.authorPeraçoli, José Carlos [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:22Z
dc.date.available2014-05-20T13:35:22Z
dc.date.issued2011-01-01
dc.description.abstractOBJECTIVES: to evaluate the structural and functional heart abnormalities in women with mitral regurgitation during pregnancy.INTRODUCTION: Women with mitral regurgitation progress well during pregnancy. However, the effects on the heart of the association between pregnancy and mitral regurgitation are not well established.METHODS: This is a case-control, longitudinal prospective study. Echocardiograms were performed in 18 women with mitral regurgitation at the 12th and 36th week of pregnancy and on the 45th day of the puerperium. Twelve age-matched healthy and pregnant women were included as controls and underwent the same evaluation as the study group.RESULTS: Compared with controls, women with mitral regurgitation presented increased left cardiac chambers in all evaluations. Increasing left atrium during pregnancy occurred only in the mitral regurgitation group. At the end of the puerperium, women with mitral regurgitation showed persistent enlargement of the left atrium compared with the beginning of pregnancy (5.0 +/- 1.1 cm vs 4.6 +/- 0.9 cm; p < 0.05). Reduced left ventricular relative wall thickness (0.13 +/- 0.02 vs 0.16 +/- 0.02; p < 0.05) and an increased peak of afterload (278 +/- 55 g/cm(2) vs 207 +/- 28 g/cm(2); p < 0.05) was still observed on the 45th day after delivery in the mitral regurgitation group compared with controls.CONCLUSIONS: Pregnancy causes unfavorable structural alterations in women with mitral regurgitation that are associated with an aggravation of the hemodynamic overload.en
dc.description.affiliationUNESP São Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynaecol, São Paulo, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynaecol, São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Botucatu Med Sch, Dept Internal Med, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent47-50
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322011000100009
dc.identifier.citationClinics. São Paulo: Hospital Clinicas, Univ São Paulo, v. 66, n. 1, p. 47-50, 2011.
dc.identifier.doi10.1590/S1807-59322011000100009
dc.identifier.fileWOS000288712700009.pdf
dc.identifier.issn1807-5932
dc.identifier.lattes6990977122340795
dc.identifier.lattes8499437381595614
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.scieloS1807-59322011000100009
dc.identifier.urihttp://hdl.handle.net/11449/12159
dc.identifier.wosWOS:000288712700009
dc.language.isoeng
dc.publisherUniversidade de São Paulo (USP), Hospital das Clínicas
dc.relation.ispartofClinics
dc.relation.ispartofjcr1.245
dc.relation.ispartofsjr0,536
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMitral regurgitationen
dc.subjectPregnancyen
dc.subjectEchocardiogramen
dc.subjectVentricular functionen
dc.subjectCardiac remodelingen
dc.titleEffect of physiological overload on pregnancy in women with mitral regurgitationen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/clin/paboutj.htm
dcterms.rightsHolderHospital Clinicas, Univ São Paulo
unesp.author.lattes6990977122340795
unesp.author.lattes8499437381595614
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0002-9227-832X[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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