A synthesis of captopril through a Baylis-Hillman reaction

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dc.contributor.authorFeltrin, M. P.
dc.contributor.authorAlmeida, W. P.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:54:34Z
dc.date.available2015-03-18T15:54:34Z
dc.date.issued2003-01-01
dc.description.abstractA synthesis of the antihipertensive amide 1, named captopril, is described. The strategy is based on a Baylis-Hillman reaction between N-acryloylproline and formaldehyde. Subsequential diastereoselective hydrogenation step and functional group interconversion provided captopril in good overall yield.en
dc.description.affiliationUniv Estadual Paulista, Inst Ciencias Saude, BR-13055044 Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Ciencias Saude, BR-13055044 Campinas, SP, Brazil
dc.format.extent1141-1146
dc.identifierhttp://dx.doi.org/10.1081/SCC-120017189
dc.identifier.citationSynthetic Communications. New York: Marcel Dekker Inc, v. 33, n. 7, p. 1141-1146, 2003.
dc.identifier.doi10.1081/SCC-120017189
dc.identifier.issn0039-7911
dc.identifier.urihttp://hdl.handle.net/11449/116965
dc.identifier.wosWOS:000182804200011
dc.language.isoeng
dc.publisherMarcel Dekker Inc
dc.relation.ispartofSynthetic Communications
dc.relation.ispartofjcr1.377
dc.relation.ispartofsjr0,328
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleA synthesis of captopril through a Baylis-Hillman reactionen
dc.typeArtigo
dcterms.rightsHolderMarcel Dekker Inc

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