Insights on β-glucan as a prebiotic coadjuvant in the treatment of diabetes mellitus: A review

dc.contributor.authorSivieri, Katia [UNESP]
dc.contributor.authorde Oliveira, Sonia Mariza
dc.contributor.authorMarquez, Audrey de Souza
dc.contributor.authorPérez-Jiménez, Jara
dc.contributor.authorDiniz, Susana Nogueira
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionInstitute of Food Science
dc.contributor.institutionUniversity Pitágoras Unopar (UNOPAR)
dc.date.accessioned2023-07-29T12:52:34Z
dc.date.available2023-07-29T12:52:34Z
dc.date.issued2022-12-01
dc.description.abstractThe prevalence of Diabetes Mellitus and, particularly, type 2 diabetes (T2D) is increasing every year worldwide. Therefore, changed glucose homeostasis is associated with altered gut microbiota and with the development of type 2 diabetes mellitus (T2DM) and related complications. Among other concerns, an important aspect within this issue is the reversion of dysbiosis reported to be present in T2D patients, in which diet plays a key role, and particularly dietary fiber has shown a promising position. β-glucans are heterogeneous non-starch polysaccharides, constituted by D-glucose monomers linked through different β-glycosidic bonds, and changes in their structure or molecular weight affect the expressed biological properties. They appear in certain cereals, yeasts, or mushrooms and are widely known by their hypocholesterolemia effect. This study explored the current knowledge on the potential of β-glucans to modulate glucose homeostasis due to their prebiotic action, by performing a bibliometric analysis using the VOSviewer software and a narrative review. The bibliometric analysis showed that, despite the high number of references dealing with β-glucan and diabetes, there are few articles on glucans, diabetes, and intestinal dysbiosis. The detailed study on preclinical studies and clinical trials conducted during the last decade showed an improvement in glucose homeostasis due to β-glucan supplementation, studies on biochemical markers, and gut microbiota, and β-glucan are scarce. Nevertheless, existing data showed, both in animals and humans, a tendency towards an increase in beneficial bacteria and in the production of short-chain fat acids (SCFAs), particularly butyric acid. These aspects should be confirmed in the years to come to establish clear recommendations for β-glucan as a prebiotic coadjutant in the management of Diabetes Mellitus.en
dc.description.affiliationBiotechnology and Health Innovation Anhanguera University of São Paulo
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University, Araraquara
dc.description.affiliationAnhanguera University of São Paulo
dc.description.affiliationTechnology and Nutrition Spanish Research Council (ICTAN-CSIC) Institute of Food Science
dc.description.affiliationCenter of Research in Health Sciences University Pitágoras Unopar (UNOPAR)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University, Araraquara
dc.identifierhttp://dx.doi.org/10.1016/j.fhfh.2022.100056
dc.identifier.citationFood Hydrocolloids for Health, v. 2.
dc.identifier.doi10.1016/j.fhfh.2022.100056
dc.identifier.issn2667-0259
dc.identifier.scopus2-s2.0-85148478807
dc.identifier.urihttp://hdl.handle.net/11449/246862
dc.language.isoeng
dc.relation.ispartofFood Hydrocolloids for Health
dc.sourceScopus
dc.subjectBeta-glucan
dc.subjectGlycemic control
dc.subjectMicrobiota dysbiosis
dc.subjectMicrobiota modulation
dc.subjectShort-chain fat acids
dc.titleInsights on β-glucan as a prebiotic coadjuvant in the treatment of diabetes mellitus: A reviewen
dc.typeResenha

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