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Evaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitamin

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dc.contributor.authorAlmeida, Danielle Ayr Tavares de
dc.contributor.authorBraga, Camila Pereira [UNESP]
dc.contributor.authorNovelli, Ethel Lourenzi Barbosa [UNESP]
dc.contributor.authorFernandes, Ana Angélica Henrique [UNESP]
dc.contributor.institutionUniversidade Federal do Mato Grosso
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:53:23Z
dc.date.available2014-05-20T13:53:23Z
dc.date.issued2012-08-01
dc.description.abstractThe present study investigated the effect of supplementation of vitamin E on streptozotocin (STZ)-induced diabetic rats by measuring blood glucose, changes in body weight, food and water intake, lipid profile, serum urea and creatinine level, and antioxidant enzyme activity. Male Wistar rats were divided into four groups: control rats (GI); rats receiving vitamin E (GII); STZ-induced diabetic rats (GIII) and STZ-induced diabetic rats treated with vitamin E (GIV). Vitamin E reduced (p<0.05) blood glucose and urea, improved the lipid profile (decreased the serum levels of total cholesterol, LDL cholesterol, VLDL cholesterol and triacylglycerols, and increased HDL cholesterol) and increased total protein in STZ-induced diabetic rats (GIV). Vitamin prevented changes in the activity of SOD and GSH-Px and in the concentration of lipid hydroperoxide. These results suggested that vitamin E improved hyperglycaemia and dyslipidaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats.en
dc.description.affiliationUniversidade Federal do Mato Grosso
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Química e Bioquímica
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Química e Bioquímica
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent527-536
dc.identifierhttp://dx.doi.org/10.1590/S1516-89132012000400007
dc.identifier.citationBrazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 4, p. 527-536, 2012.
dc.identifier.doi10.1590/S1516-89132012000400007
dc.identifier.fileS1516-89132012000400007.pdf
dc.identifier.issn1516-8913
dc.identifier.scieloS1516-89132012000400007
dc.identifier.urihttp://hdl.handle.net/11449/19054
dc.identifier.wosWOS:000307710200007
dc.language.isoeng
dc.publisherBrazilian Archives of Biology and Technology
dc.relation.ispartofBrazilian Archives of Biology and Technology
dc.relation.ispartofjcr0.676
dc.relation.ispartofsjr0,281
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectvitamin Een
dc.subjectlipid profileen
dc.subjectoxidative stressen
dc.subjectSTZen
dc.titleEvaluation of lipid profile and oxidative stress in STZ-induced rats treated with antioxidant vitaminen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/babt/paboutj.htm
dspace.entity.typePublication
unesp.author.lattes0077247086732148[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentQuímica e Bioquímica - IBBpt

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Botucatu - IBB - Instituto de Biociências