Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men

dc.contributor.authorNascimento, M. A.
dc.contributor.authorHiga, E. M.S.
dc.contributor.authorde Mello, M. T.
dc.contributor.authorTufik, S.
dc.contributor.authorOyama, L. M.
dc.contributor.authorSantos, R. V.
dc.contributor.authorAmaya Farfan, J.
dc.contributor.authorRisso, E. M.
dc.contributor.authorDe Souza, C. T.
dc.contributor.authorPimentel, G. D.
dc.contributor.authorLira, F. S. [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionLaboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:37:37Z
dc.date.available2018-12-11T16:37:37Z
dc.date.issued2014-01-01
dc.description.abstractBackground & aim: Dyslipidemia is involved with in development of cardiovascular diseases and obesity, exercise is recommended as a successful intervention. Dietary l-arginine (l-arg) supplementation may improve in lipid metabolism. However, these combined strategies on lipid profile were not tested yet. This study examines the effects of short term of l-arg supplementation and acute resistance exercise (AREX) on the blood lipid profile and inflammatory proteins in overweight men. Methods: Seven overweight men, 46±5yrs, body weight 93.1±12.0Kg and BMI 31.7±3kg/m2, participated in a randomized, double-blind and crossover study, distributed into exercise groups, based on the supplementation (6g/day of placebo or Arginine for 7 days). Supplementation periods were separated by 7-days of wash-out. The AREX was comprised of eight exercises, with an exercise intensity of 60% 1RM. The glucose, lipid profile (NEFA, triglycerides, HDL cholesterol, LDL cholesterol and total cholesterol) and inflammatory proteins [plasminogen activator inhibitor-1 (PAI-1) and adiponectin] were determined at rest, immediately, after exercise and 1h after exercise sessions. Results: Triglycerides, total cholesterol, and adiponectin levels not showed time-dependent changes under the different conditions. LDL cholesterol and NEFA levels decreased after 1h recovery periods when compared to rest periods only in l-arg supplementation group (P<0.05). PAI-1 was reduced and HDL cholesterol exhibits increases immediately after AREX and 1h recovery periods when compared with rest periods in both groups (P<0.05). Conclusion: These results indicate that l-arg supplementation can potentiate the effects of exercise inducing changes in the LDL cholesterol and NEFA levels. © 2014 European Society for Clinical Nutrition and Metabolism.en
dc.description.affiliationTranslational Medicine, Universidade Federal de São Paulo
dc.description.affiliationNephrology Department, Universidade Federal de São Paulo
dc.description.affiliationCentro de Estudos em Psicobiologia e Exercício (CEPE), Universidade Federal de São Paulo
dc.description.affiliationPsychobiology Department, Universidade Federal de São Paulo
dc.description.affiliationPhysiology Department, Universidade Federal de São Paulo
dc.description.affiliationBioscience Department, Universidade Federal de São Paulo
dc.description.affiliationFood and Nutrition Department, University of Campinas
dc.description.affiliationInternal Medicine Department, University of Campinas
dc.description.affiliationLaboratory of Exercise Biochemistry and Physiology, Universidade do Extremo Sul Catarinense, SC
dc.description.affiliationDepartment of Physical Education, São Paulo State University, UNESP, SP
dc.description.affiliationUnespDepartment of Physical Education, São Paulo State University, UNESP, SP
dc.identifierhttp://dx.doi.org/10.1016/j.clnme.2014.02.002
dc.identifier.citatione-SPEN Journal, v. 9, n. 3, 2014.
dc.identifier.doi10.1016/j.clnme.2014.02.002
dc.identifier.file2-s2.0-84901495036.pdf
dc.identifier.issn2212-8263
dc.identifier.scopus2-s2.0-84901495036
dc.identifier.urihttp://hdl.handle.net/11449/167616
dc.language.isoeng
dc.relation.ispartofe-SPEN Journal
dc.relation.ispartofsjr0,194
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectArginine supplementation
dc.subjectDyslipidemia
dc.subjectOverweight
dc.subjectPlasminogen activator inhibitor-1
dc.subjectResistance exercise
dc.titleEffects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight menen
dc.typeArtigo

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