Evaluation of effect of cyclosporine A on the bone tissue with induced periodontal disease to ligature in rats

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dc.contributor.authorNassar, P. O.
dc.contributor.authorFelipetti, F. A.
dc.contributor.authorNassar, C. A.
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual do Oeste do Paraná (UNIOESTE)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:35Z
dc.date.available2014-05-27T11:28:35Z
dc.date.issued2013-03-01
dc.description.abstractThe administration of cyclosporine A (CsA) has been associated with significant bone loss and increased bone remodeling. The present investigation was designed to evaluate the effects of CsA on alveolar bone of rats subjected to experimental periodontitis, using histomorphometric and histological analysis. Twenty-four rats were divided into groups with 6 animals each: 1, control; 2, rats with ligature around the lower first molars; 3, rats with ligature around the lower first molars and that were treated with 10 mg CsA/kg of body weight/d; and 4, rats treated with 10 mg CsA/kg of body weight/d. At the end of 30 days, rats were humanely killed and subjected to a histological processing, with analysis of the distance cemento-enamel junction and alveolar bone crest, bone area, eroded bone area, and cemento surface. All of them were assessed at the mesial region of the alveolar bone. The CsA therapy combined with ligature placement decreased bone area and increased the eroded bone area around the tooth surface. The results at the histological analysis showed the same combination and changes. Therefore, in spite of the lack of a direct effect on the alveolar bone height, the CsA therapy intensified the imbalance of the alveolar bone homeostasia in a rat model of experimental periodontitis. © 2013 Elsevier Inc.en
dc.description.affiliationDepartment of Periodontology Cascavel Dental School State University of West of Parana (UNIOESTE) Cascavel, Parana
dc.description.affiliationDepartment of Oral Pathology Araraquara Dental School State University of São Paulo (UNESP) Araraquara, São Paulo
dc.description.affiliationBiosciences and Health State University of West of Parana (UNIOESTE) Cascavel, Parana
dc.description.affiliationUnespDepartment of Oral Pathology Araraquara Dental School State University of São Paulo (UNESP) Araraquara, São Paulo
dc.format.extent778-782
dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2012.02.029
dc.identifier.citationTransplantation Proceedings, v. 45, n. 2, p. 778-782, 2013.
dc.identifier.doi10.1016/j.transproceed.2012.02.029
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.lattes2640929291808415
dc.identifier.scopus2-s2.0-84875220312
dc.identifier.urihttp://hdl.handle.net/11449/74691
dc.identifier.wosWOS:000316772500053
dc.language.isoeng
dc.relation.ispartofTransplantation Proceedings
dc.relation.ispartofjcr0.806
dc.relation.ispartofsjr0,422
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectcyclosporin A
dc.subjectsandimmum neoral
dc.subjectunclassified drug
dc.subjectalveolar bone
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectbone tissue
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjecthistopathology
dc.subjectmale
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectperiodontal disease
dc.subjectperiodontitis
dc.subjectpriority journal
dc.subjectrat
dc.subjectAlveolar Bone Loss
dc.subjectAlveolar Process
dc.subjectAnimals
dc.subjectBone Remodeling
dc.subjectCyclosporine
dc.subjectDisease Models, Animal
dc.subjectImmunosuppressive Agents
dc.subjectLigation
dc.subjectMale
dc.subjectMolar
dc.subjectPeriodontitis
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectTime Factors
dc.titleEvaluation of effect of cyclosporine A on the bone tissue with induced periodontal disease to ligature in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes2640929291808415
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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