Distribution of melanin-concentrating hormone neurons projecting to the medial mammillary nucleus

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dc.contributor.authorCasatti, C. A. [UNESP]
dc.contributor.authorElias, C. F.
dc.contributor.authorSita, L. V.
dc.contributor.authorFrigo, L.
dc.contributor.authorFurlani, V. C. G.
dc.contributor.authorBauer, J. A.
dc.contributor.authorBittencourt, J. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Cruzeiro do Sul (UNICSUL)
dc.date.accessioned2015-12-07T15:29:38Z
dc.date.available2015-12-07T15:29:38Z
dc.date.issued2002
dc.description.abstractThe melanin-concentrating hormone and neuropeptide glutamic acid-isoleucine are expressed in neurons located mainly in the hypothalamus that project widely throughout the CNS. One of the melanin-concentrating hormone main targets is the medial mammillary nucleus, but the exact origin of these fibers is unknown. We observed melanin-concentrating hormone and neuropeptide glutamic acid-isoleucine immunoreactive fibers coursing throughout the mammillary complex, showing higher density in the pars lateralis of the medial mammillary nucleus, while the lateral mammillary nucleus showed sparse melanin-concentrating hormone innervation. The origins of these afferents were determined by using implant of the retrograde tracer True Blue in the medial mammillary nucleus. Double-labeled neurons were observed in the lateral hypothalamic area, rostromedial zona incerta and dorsal tuberomammillary nucleus. A considerable population of retrogradely labeled melanin-concentrating hormone perikaryal profiles was also immunoreactive to neuropeptide glutamic acid-isoleucine (74+/-15% to 85+/-15%). The afferents from the lateral hypothalamic area, rostromedial zona incerta and dorsal tuberomammillary nucleus to the medial mammillary nucleus were confirmed using implant of the anterograde tracer Phaseolus vulgaris leucoagglutinin. In addition, using double-labeled immunohistochemistry, we found no co-localization between neurons expressing melanin-concentrating hormone and adenosine deaminase (histaminergic marker) in the dorsal tuberomammillary nucleus. We hypothesize that these melanin-concentrating hormone projections participate in spatial memory process mediated by the medial mammillary nucleus. These pathways would enable the animal to look for food during the initial moments of appetite stimulation.en
dc.description.affiliationLaboratory of Chemical Neuroanatomy, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo – USP, 05508-900 Sao Paulo, Brazil
dc.description.affiliationCenter for Research in Neuroscience and Behavior, Institute of Psychology, University of Sao Paulo – USP, 05508-900 Sao Paulo, Brazil
dc.description.affiliationUniversity of Cruzeiro do Sul – UNICSUL, 08060-070 Sao Paulo, Brazil
dc.description.affiliationDepartment of Histology and Embryology, Institute of Biomedical Sciences, University of Sao Paulo – USP, 05508-900 Sao Paulo, Brazil.
dc.description.affiliationUnespDepartment of Basic Sciences, School of Dentistry of Araçatuba, University of São Paulo State - UNESP, 16015-050, São Paulo, Araçatuba, Brazil.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 1990/3170-0
dc.description.sponsorshipIdFAPESP: 1990/3675-5
dc.description.sponsorshipIdFAPESP: 1999/03490-0
dc.format.extent899-915
dc.identifierhttp://dx.doi.org/10.1016/S0306-4522(02)00508-0
dc.identifier.citationNeuroscience, v. 115, n. 3, p. 899-915, 2002.
dc.identifier.doi10.1016/S0306-4522(02)00508-0
dc.identifier.issn0306-4522
dc.identifier.lattes8487462626931877
dc.identifier.orcid0000-0001-5650-7343
dc.identifier.pubmed12435428
dc.identifier.urihttp://hdl.handle.net/11449/130828
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofNeuroscience
dc.relation.ispartofjcr3.382
dc.relation.ispartofsjr1,602
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectFood intakeen
dc.subjectLateral hypothalamic areaen
dc.subjectMammillary bodyen
dc.subjectRostromedial zona incertaen
dc.subjectSpatial memoryen
dc.subjectTuberomammillary nucleusen
dc.titleDistribution of melanin-concentrating hormone neurons projecting to the medial mammillary nucleusen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
unesp.author.lattes8487462626931877[1]
unesp.author.orcid0000-0001-5650-7343[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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