Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer

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dc.contributor.authorReis, Juliana Santana [UNESP]
dc.contributor.authorCorrea, Marcos Antonio [UNESP]
dc.contributor.authorChin, Chung Man [UNESP]
dc.contributor.authorSantos, Jean Leandro dos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:44Z
dc.date.available2014-12-03T13:11:44Z
dc.date.issued2014-05-01
dc.description.abstractChronic ultraviolet (UV) radiation exposure is a major cause of skin cancer. A novel series of hybrid derivatives (I-VIII) for use in sunscreen formulations were synthesized by molecular hybridization of t-resveratrol, avobenzone, and octyl methoxycinnamate, and were characterized. The antioxidant activity values for VIII were comparable than to those of t-resveratrol. Compounds I-III and VI demonstrated Sun Protector Factor superior to that of t-resveratrol. Compounds I and IV-VIII were identified as new, broad-spectrum UVA filters while II-III were UVB filters. In conclusion, novel hybrid derivatives with antioxidant effects have emerged as novel photoprotective agents for the prevention of skin cancer. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 12/09237-0
dc.format.extent2733-2738
dc.identifierhttp://dx.doi.org/10.1016/j.bmc.2014.03.017
dc.identifier.citationBioorganic & Medicinal Chemistry. Oxford: Pergamon-elsevier Science Ltd, v. 22, n. 9, p. 2733-2738, 2014.
dc.identifier.doi10.1016/j.bmc.2014.03.017
dc.identifier.issn0968-0896
dc.identifier.lattes3316011688829943
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.urihttp://hdl.handle.net/11449/113473
dc.identifier.wosWOS:000334744100017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBioorganic & Medicinal Chemistry
dc.relation.ispartofjcr2.881
dc.relation.ispartofsjr0,871
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSunscreensen
dc.subjectPhotoprotectionen
dc.subjectAntioxidanten
dc.subjectUV radiationen
dc.subjectUV filtersen
dc.subjectt-Resveratrolen
dc.subjectAvobenzoneen
dc.subjectOctyl methoxycinnamateen
dc.subjectMolecular hybridizationen
dc.titleSynthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin canceren
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3316011688829943
unesp.author.lattes9734333607975413[3]
unesp.author.orcid0000-0002-2460-2829[4]
unesp.author.orcid0000-0003-4141-0455[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR