Avaliação da biocompatibilidade da membrana de acetato de celulose em cães com insuficiência renal aguda submetidos à hemodiálise

Abstract

In order to evaluate the biocompatibility of the membrane of cellulose acetate in dogs with acute renal failure (ARF), undergoing hemodialysis, were used two groups, one consisting of eight normal dogs and the other by eight dogs with ARF induced by gentamicin. Each animal underwent five hemodialysis sessions, with intervals of 24 hours between each one. A significant reduction in urea and creatinine, whereas the other biochemical values were not different between groups, as well as blood pressure, red cell count, white blood cell count and activated clotting time. High levels of TNF-α was found in sick animals, with no detection of this cytokine in normal animals.