Lack of correlation between periodontitis and renal dysfunction in systemically healthy patients

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dc.contributor.authorBrotto, Renata Squariz [UNESP]
dc.contributor.authorVendramini, Regina Célia [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorMarcantonio, Rosemary Adriana Chierici [UNESP]
dc.contributor.authorRamos, Adriana Pelegrino Pinho
dc.contributor.authorPepato, Maria Teresa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Ribeirão Preto (UNAERP)
dc.date.accessioned2014-05-27T11:25:27Z
dc.date.available2014-05-27T11:25:27Z
dc.date.issued2011-01-01
dc.description.abstractObjectives: The aim of this study was to assess a suggested association between periodontitis and renal insufficiency by assaying kidney disease markers. Methods: Variables used to diagnose periodontitis were: (i) probing pocket depth (PPD), (ii) attachment loss (AL), (iii) bleeding on probing (BOP), (iv) plaque index (PI) and (v) extent and severity index. Blood and urine were collected from 60 apparently healthy non-smokers (men and women), consisting of a test group of 30 subjects with periodontitis (age 46±6 yrs) and a control group of 30 healthy subjects (age 43±5 yrs). Kidney function markers (urea, creatinine, uric acid and albumin contents) were measured in the serum and urine. Also, the glomerular filtration rate was estimated from creatinine clearance, from the abbreviated Modification of Diet in Renal Disease formula and from the albumin: creatinine ratio in a 24-h sample of urine. Results: It was found that the control group had a greater mean number of teeth than the test group and that the two groups also differed in PPD, AL, BOP and PI, all these variables being higher in the test group (P=0.006). For the extent and severity index of both PPD and AL, the test group had much higher medians of both extent and severity than the control group (P=0.001). With regard to kidney function, none of the markers revealed a significant difference between the control and test groups and all measured values fell within the reference intervals. Conclusions: It is proposed that severe periodontitis is not associated with any alteration in kidney function.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Araraquara UNESP, Univ Estadual Paulista Departamento de Análises Clínicas, SP
dc.description.affiliationFaculdade de Odontologia de Araraquara UNESP, Univ Estadual Paulista Departamento de Diagnóstico e Cirurgia, SP
dc.description.affiliationLaboratório de Análises Clínicas do Curso de Ciências Farmaceuticas Universidade de Ribeirão Preto (UNAERP), São Paulo
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas de Araraquara UNESP, Univ Estadual Paulista Departamento de Análises Clínicas, SP
dc.description.affiliationUnespFaculdade de Odontologia de Araraquara UNESP, Univ Estadual Paulista Departamento de Diagnóstico e Cirurgia, SP
dc.format.extent8-18
dc.identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019747/
dc.identifier.citationEuropean Journal of Dentistry, v. 5, n. 1, p. 8-18, 2011.
dc.identifier.file2-s2.0-79958012341.pdf
dc.identifier.issn1305-7456
dc.identifier.issn1305-7464
dc.identifier.lattes3534044399884035
dc.identifier.scopus2-s2.0-79958012341
dc.identifier.urihttp://hdl.handle.net/11449/72293
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Dentistry
dc.relation.ispartofsjr0,749
dc.relation.ispartofsjr0,749
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAlbumin
dc.subjectCreatinine clearance
dc.subjectKidney function markers
dc.subjectUrea
dc.subjectUric acid
dc.titleLack of correlation between periodontitis and renal dysfunction in systemically healthy patientsen
dc.typeArtigo
dcterms.licensehttp://www.eurjdent.com/aboutus.asp
unesp.author.lattes3534044399884035
unesp.author.orcid0000-0002-5052-7439[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Artigos - Diagnóstico e Cirurgia - FOAR