Nanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healing

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dc.contributor.authorCosta-Fernandez, Sandra
dc.contributor.authorMatos, Jenyffer K.R.
dc.contributor.authorScheunemann, Gaby S.
dc.contributor.authorSalata, Giovanna C.
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorWatanabe, Il-Sei
dc.contributor.authorde Araujo, Gabriel L.B.
dc.contributor.authorSantos, Marinilce F.
dc.contributor.authorIshida, Kelly
dc.contributor.authorLopes, Luciana B.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T11:15:38Z
dc.date.available2021-06-25T11:15:38Z
dc.date.issued2021-07-31
dc.description.abstractThe high incidence and costs of chronic wounds in the elderly have motivated the search for innovations to improve product performance and the healing process while reducing costs. In this study, bioadhesive nanostructured lipid carriers (NLC) were developed for the co-encapsulation of compounds with antioxidant (α-tocopherol and quercetin) and antimicrobial (tea tree oil) activity for management of wounds. The NLC was produced with shea butter and argan oil, and modified with sodium alginate or chitosan to confer bioadhesive properties. Spherical nanoparticles of ~307–330 nm and zeta potential varying from −21.2 to +11.8 mV were obtained. Thermal analysis demonstrated that the lipid matrix reduced tea tree oil thermal loss (~1.8-fold). Regardless of the type of polysaccharide employed, the NLCs promoted cutaneous localization of antioxidants in damaged (subjected to incision) skin, with a ~74 to 180-fold higher delivery into the skin compared to percutaneous delivery. This result is consistent with the similar bioadhesive properties of chitosan or sodium alginate-modified NLC. Nanoencapsulation of tea tree oil did not preclude its antimicrobial effects against susceptible and resistant strains of S. aureus and P. aeruginosa, while co-encapsulation of antioxidants increased the NLC-induced fibroblasts migration, supporting their potential usefulness for management of wounds.en
dc.description.affiliationInstituto de Ciências Biomédicas Universidade de São Paulo
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade de São Paulo
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdFAPESP: 2013/16617-7
dc.description.sponsorshipIdFAPESP: 2015/07993-0
dc.description.sponsorshipIdFAPESP: 2017/19059-6
dc.description.sponsorshipIdFAPESP: 2017/19374-9
dc.description.sponsorshipIdFAPESP: 2018/13877-1
dc.description.sponsorshipIdFAPESP: 2019/26048-6
dc.description.sponsorshipIdCNPq: 306866/2020-0
dc.format.extent668-680
dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2021.04.168
dc.identifier.citationInternational Journal of Biological Macromolecules, v. 183, p. 668-680.
dc.identifier.doi10.1016/j.ijbiomac.2021.04.168
dc.identifier.issn1879-0003
dc.identifier.issn0141-8130
dc.identifier.scopus2-s2.0-85105351087
dc.identifier.urihttp://hdl.handle.net/11449/208652
dc.language.isoeng
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.sourceScopus
dc.subjectAntimicrobial
dc.subjectAntioxidants
dc.subjectBioadhesion
dc.subjectNanostructured lipid carriers
dc.subjectWound healing
dc.titleNanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healingen
dc.typeArtigo
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas