Antifungal activity of extracts and isolated compounds from Buchenavia tomentosa on Candida albicans and non-albicans

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dc.contributor.authorTeodoro, Guilherme R. [UNESP]
dc.contributor.authorBrighenti, Fernanda Lourenção [UNESP]
dc.contributor.authorDelbem, Alberto C. Botazzo [UNESP]
dc.contributor.authorDelbem, Ádina Cléia B. [UNESP]
dc.contributor.authorKhouri, Sonia
dc.contributor.authorGontijo, Aline Vidal L. [UNESP]
dc.contributor.authorPascoal, Aislan C. R.F.
dc.contributor.authorSalvador, Marcos J.
dc.contributor.authorKoga-Ito, Cristiane Y. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Vale do Paraíba (UNIVAP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2015-08-06T16:12:13Z
dc.date.available2015-08-06T16:12:13Z
dc.date.issued2015
dc.description.abstractAim: This study aimed to evaluate the antifungal activity of Buchenavia tomentosa extract and bioactive compounds on six Candida species. Materials & methods: The antimicrobial activity of extract was evaluated using standard strains and clinical isolates. Cytotoxicity was tested in order to evaluate cell damage caused by the extract. Extract was chemically characterized and the antifungal activity of its compounds was evaluated. Results: Extract showed antifungal activity on Candida species. Candida non-albicans were more susceptible than Candida albicans. Low cytotoxicity for extract was observed. The isolated compounds presented antifungal activity at least against one Candida spp. and all compounds presented antifungal effect on Candida glabrata. Conclusion: Extracts from Buchenavia tomentosa showed promising antifungal activity on Candida species with low cytotoxicity. Gallic acid, corilagin and ellagic acid showed promising inhibitory activity on Candida glabrata.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680 - Departamento de Clínica Infantil, Centro, CEP 14801903, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680 - Departamento de Clínica Infantil, Centro, CEP 14801903, SP, Brasil
dc.format.extent917-927
dc.identifierhttp://www.futuremedicine.com/doi/10.2217/fmb.15.20
dc.identifier.citationFuture Microbiology, v. 10, n. 6, p. 917-927, 2015.
dc.identifier.doi10.2217/fmb.15.20
dc.identifier.issn1746-0913
dc.identifier.lattes6065636367717382
dc.identifier.lattes6543563161403421
dc.identifier.orcid0000-0002-4470-5171
dc.identifier.orcid0000-0002-2416-2173
dc.identifier.urihttp://hdl.handle.net/11449/125483
dc.language.isoeng
dc.relation.ispartofFuture Microbiology
dc.relation.ispartofjcr3.190
dc.relation.ispartofsjr1,270
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectCandida albicansen
dc.subjectCandida non-albicansen
dc.subjectAntifungal agentsen
dc.subjectNatural compoundsen
dc.titleAntifungal activity of extracts and isolated compounds from Buchenavia tomentosa on Candida albicans and non-albicansen
dc.typeArtigo
unesp.author.lattes6065636367717382[2]
unesp.author.lattes0421571920582994[3]
unesp.author.lattes6543563161403421[9]
unesp.author.orcid0000-0002-8159-4853[3]
unesp.author.orcid0000-0002-8159-4853[3]
unesp.author.orcid0000-0002-4470-5171[2]
unesp.author.orcid0000-0002-2416-2173[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.departmentClínica Infantil - FOARpt

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Araraquara - FOAR - Faculdade de Odontologia