Genomic Regions Associated with Feed Efficiency Indicator Traits in an Experimental Nellore Cattle Population

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dc.contributor.authorOlivieri, Bianca Ferreira [UNESP]
dc.contributor.authorZerlotti Mercadante, Maria Eugenia
dc.contributor.authorSantos Goncalves Cyrillo, Joslaine Noely dos
dc.contributor.authorBranco, Renata Helena
dc.contributor.authorMartins Bonilha, Sarah Figueiredo
dc.contributor.authorAlbuquerque, Lucia Galvao de [UNESP]
dc.contributor.authorOliveira Silva, Rafael Medeiros de [UNESP]
dc.contributor.authorBaldi, Fernando [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCtr Avancado Pesquisa Tecnol Agronegocio Bovinos
dc.date.accessioned2018-11-26T17:07:13Z
dc.date.available2018-11-26T17:07:13Z
dc.date.issued2016-10-19
dc.description.abstractThe objective of this study was to identify genomic regions and metabolic pathways associated with dry matter intake, average daily gain, feed efficiency and residual feed intake in an experimental Nellore cattle population. The high-density SNP chip (Illumina High-Density Bovine BeadChip, 777k) was used to genotype the animals. The SNP markers effects and their variances were estimated using the single-step genome wide association method. The (co)variance components were estimated by Bayesian inference. The chromosome segments that are responsible for more than 1.0% of additive genetic variance were selected to explore and determine possible quantitative trait loci. The bovine genome Map Viewer was used to identify genes. In total, 51 genomic regions were identified for all analyzed traits. The heritability estimated for feed efficiency was low magnitude (0.13 +/- 0.06). For average daily gain, dry matter intake and residual feed intake, heritability was moderate to high (0.43 +/- 0.05; 0.47 +/- 0.05, 0.18 +/- 0.05, respectively). A total of 8, 17, 14 and 12 windows that are responsible for more than 1% of the additive genetic variance for dry matter intake, average daily gain, feed efficiency and residual feed intake, respectively, were identified. Candidate genes GOLIM4, RFX6, CACNG7, CACNG6, CAPN8, CAPN2, AKT2, GPRC6A, and GPR45 were associated with feed efficiency traits. It was expected that the response to selection would be higher for residual feed intake than for feed efficiency. Genomic regions harboring possible QTL for feed efficiency indicator traits were identified. Candidate genes identified are involved in energy use, metabolism protein, ion transport, transmembrane transport, the olfactory system, the immune system, secretion and cellular activity. The identification of these regions and their respective candidate genes should contribute to the formation of a genetic basis in Nellore cattle for feed efficiency indicator traits, and these results would support the selection for these traits.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agr & Vet, Dept Zootecnia, Via Acesso Prof Paulo Donato Castellane S-No, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationCtr Avancado Pesquisa Tecnol Agronegocio Bovinos, Inst Zootecnia, Rodovia Carlos Tonanni,Km 94, BR-14174000 Sertaozinho, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Agr & Vet, Dept Zootecnia, Via Acesso Prof Paulo Donato Castellane S-No, BR-14884900 Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2009/16118-5
dc.format.extent19
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0164390
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 11, n. 10, 19 p., 2016.
dc.identifier.doi10.1371/journal.pone.0164390
dc.identifier.fileWOS000386204000033.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11449/162086
dc.identifier.wosWOS:000386204000033
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleGenomic Regions Associated with Feed Efficiency Indicator Traits in an Experimental Nellore Cattle Populationen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science

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