Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease

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Ferrari, Renata [UNESP]
Tanni, Suzana E. [UNESP]
Caram, Laura M.O. [UNESP]
Corrêa, Corina [UNESP]
Corrêa, Camila Renata [UNESP]
Godoy, Irma de [UNESP]

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Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements [0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality [Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change [5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84], although eleven patients (21%) presented with changes >3 mg/L in CRP after 3 years. Conclusions: The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. Trial registration: No.:NCT00605540. © 2013 Ferrari et al; licensee BioMed Central Ltd.



Biomarkers, Chronic Obstructive Pulmonary Disease, Exercise, Inflammation, C reactive protein, interleukin 6, biological marker, IL6 protein, human, adult, body mass, chronic obstructive lung disease, clinical evaluation, controlled study, disease association, disease duration, disease exacerbation, enzyme linked immunosorbent assay, exercise tolerance, female, follow up, human, major clinical study, male, mortality, nutritional status, outcome assessment, prediction, proportional hazards model, prospective study, protein blood level, walking, blood, Brazil, exercise test, middle aged, prevalence, risk factor, statistics, survival, survival rate, Biological Markers, C-Reactive Protein, Exercise Test, Exercise Tolerance, Female, Follow-Up Studies, Humans, Interleukin-6, Male, Middle Aged, Prevalence, Pulmonary Disease, Chronic Obstructive, Risk Factors, Survival Analysis, Survival Rate

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Respiratory Research, v. 14, n. 1, 2013.