Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease
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2013-02-20
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Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements [0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality [Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change [5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84], although eleven patients (21%) presented with changes >3 mg/L in CRP after 3 years. Conclusions: The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. Trial registration: No.:NCT00605540. © 2013 Ferrari et al; licensee BioMed Central Ltd.
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Biomarkers , Chronic Obstructive Pulmonary Disease , Exercise , Inflammation , C reactive protein , interleukin 6 , biological marker , IL6 protein, human , adult , body mass , chronic obstructive lung disease , clinical evaluation , controlled study , disease association , disease duration , disease exacerbation , enzyme linked immunosorbent assay , exercise tolerance , female , follow up , human , major clinical study , male , mortality , nutritional status , outcome assessment , prediction , proportional hazards model , prospective study , protein blood level , walking , blood , Brazil , exercise test , middle aged , prevalence , risk factor , statistics , survival , survival rate , Biological Markers , C-Reactive Protein , Exercise Test , Exercise Tolerance , Female , Follow-Up Studies , Humans , Interleukin-6 , Male , Middle Aged , Prevalence , Pulmonary Disease, Chronic Obstructive , Risk Factors , Survival Analysis , Survival Rate
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Respiratory Research, v. 14, n. 1, 2013.