Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease
dc.contributor.author | Ferrari, Renata [UNESP] | |
dc.contributor.author | Tanni, Suzana E. [UNESP] | |
dc.contributor.author | Caram, Laura M.O. [UNESP] | |
dc.contributor.author | Corrêa, Corina [UNESP] | |
dc.contributor.author | Corrêa, Camila Renata [UNESP] | |
dc.contributor.author | Godoy, Irma de [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-27T11:28:31Z | |
dc.date.available | 2014-05-27T11:28:31Z | |
dc.date.issued | 2013-02-20 | |
dc.description.abstract | Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements [0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality [Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change [5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84], although eleven patients (21%) presented with changes >3 mg/L in CRP after 3 years. Conclusions: The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. Trial registration: No.:NCT00605540. © 2013 Ferrari et al; licensee BioMed Central Ltd. | en |
dc.description.affiliation | Faculdade de Medicina de Botucatu Univ Estadual Paulista, Unesp Disciplina de Pneumologia, Botucatu, São Paulo | |
dc.description.affiliationUnesp | Faculdade de Medicina de Botucatu Univ Estadual Paulista, Unesp Disciplina de Pneumologia, Botucatu, São Paulo | |
dc.identifier | http://dx.doi.org/10.1186/1465-9921-14-24 | |
dc.identifier.citation | Respiratory Research, v. 14, n. 1, 2013. | |
dc.identifier.doi | 10.1186/1465-9921-14-24 | |
dc.identifier.file | 2-s2.0-84873948021.pdf | |
dc.identifier.issn | 1465-9921 | |
dc.identifier.issn | 1465-993X | |
dc.identifier.lattes | 5079454858778041 | |
dc.identifier.scopus | 2-s2.0-84873948021 | |
dc.identifier.uri | http://hdl.handle.net/11449/74616 | |
dc.identifier.wos | WOS:000317734600001 | |
dc.language.iso | eng | |
dc.relation.ispartof | Respiratory Research | |
dc.relation.ispartofjcr | 3.751 | |
dc.relation.ispartofsjr | 1,644 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Biomarkers | |
dc.subject | Chronic Obstructive Pulmonary Disease | |
dc.subject | Exercise | |
dc.subject | Inflammation | |
dc.subject | C reactive protein | |
dc.subject | interleukin 6 | |
dc.subject | biological marker | |
dc.subject | IL6 protein, human | |
dc.subject | adult | |
dc.subject | body mass | |
dc.subject | chronic obstructive lung disease | |
dc.subject | clinical evaluation | |
dc.subject | controlled study | |
dc.subject | disease association | |
dc.subject | disease duration | |
dc.subject | disease exacerbation | |
dc.subject | enzyme linked immunosorbent assay | |
dc.subject | exercise tolerance | |
dc.subject | female | |
dc.subject | follow up | |
dc.subject | human | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | mortality | |
dc.subject | nutritional status | |
dc.subject | outcome assessment | |
dc.subject | prediction | |
dc.subject | proportional hazards model | |
dc.subject | prospective study | |
dc.subject | protein blood level | |
dc.subject | walking | |
dc.subject | blood | |
dc.subject | Brazil | |
dc.subject | exercise test | |
dc.subject | middle aged | |
dc.subject | prevalence | |
dc.subject | risk factor | |
dc.subject | statistics | |
dc.subject | survival | |
dc.subject | survival rate | |
dc.subject | Biological Markers | |
dc.subject | C-Reactive Protein | |
dc.subject | Exercise Test | |
dc.subject | Exercise Tolerance | |
dc.subject | Female | |
dc.subject | Follow-Up Studies | |
dc.subject | Humans | |
dc.subject | Interleukin-6 | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Prevalence | |
dc.subject | Pulmonary Disease, Chronic Obstructive | |
dc.subject | Risk Factors | |
dc.subject | Survival Analysis | |
dc.subject | Survival Rate | |
dc.title | Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease | en |
dc.type | Artigo | |
dcterms.license | http://www.biomedcentral.com/about/license | |
unesp.author.lattes | 5079454858778041 | |
unesp.author.orcid | 0000-0002-5863-2006[3] | |
unesp.author.orcid | 0000-0002-6588-5626[6] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatu | pt |
unesp.department | Clínica Médica - FMB | pt |
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