Free radical production by azomethine H: Effects on pancreatic and hepatic tissues

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Novelli, E. L B
Silva, A. M M
Monteiro, J. P.
Sacomani, L. B.
Novellif, J. L V B [UNESP]

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The antimalarial properties of azomethine H represent the basis for its use as a chemotherapeutic agent. This work was carried out in order to verify the biological side effects of azomethine H and to clarify the contribution of reactive oxygen species (ROS) in this process. It was shown that azomethine H increased serum activities of amylase, alanine transaminase (ALT) and the TEARS concentrations, in rats. No changes were observed in glutathione peroxidase and catalase activities. The drug-induced tissue damage might be due to superoxide radicals (O-2(.-)), since Cu-Zn superoxide dismutase activities were increased by azomethine I-I treatment. This study allows tentative conclusions to be drawn regarding which reactive oxygen metabolites play a role in azomethine H activity. We concluded that (O-2(.-)) maybe produced as a mediator of azomethine H action.



Azomethine H, Cu-Zn superoxide dismutase, Glutathione peroxidase, Superoxide radical, Toxicity, alanine aminotransferase, amylase, antimalarial agent, azomethine h, catalase, copper zinc superoxide dismutase, free radical, glutathione peroxidase, reactive oxygen metabolite, superoxide, thiobarbituric acid reactive substance, unclassified drug, alanine aminotransferase blood level, amylase blood level, animal experiment, animal tissue, controlled study, dose response, enzyme activity, intraperitoneal drug administration, male, nonhuman, rat, tissue injury, Alanine Transaminase, Amylases, Animals, Antimalarials, Catalase, Dose-Response Relationship, Drug, Free Radicals, Glutathione Peroxidase, Liver, Male, Naphthalenesulfonates, Pancreas, Rats, Rats, Wistar, Reactive Oxygen Species, Superoxide Dismutase, Superoxides, Thiobarbituric Acid Reactive Substances, Thiosemicarbazones, Animalia

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Free Radical Research, v. 26, n. 4, p. 319-324, 1997.