Fluoride does not induce DNA breakage in Chinese hamster ovary cells in vitro.

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dc.contributor.authorRibeiro, Daniel Araki
dc.contributor.authorScolastici, Clarissa
dc.contributor.authorMarques, Mariângela Esther Alencar [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:06Z
dc.date.available2014-05-27T11:21:06Z
dc.date.issued2004-07-01
dc.description.abstractFluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury to genetic material. Genotoxicity tests represent an important part of cancer research to assess the risk of potential carcinogens. In the current study, the potential DNA damage associated with exposure to fluoride was assessed by the single cell gel (comet) assay in vitro. Chinese hamster ovary cells were exposed to sodium fluoride (NaF) at final concentration ranging from 7 to 100 micro/ml for 3 h, at 37 dgrees C. The results pointed out that NaF in all concentrations tested did not contribute to DNA damage as depicted by the mean tail moment and tail intensity. These findings are clinically important since they represent an important contribution to a correct evaluation of the potential health risk associated with the exposure to dental agents.en
dc.format.extent192-196
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242004000300003
dc.identifier.citationPesquisa odontologica brasileira = Brazilian oral research, v. 18, n. 3, p. 192-196, 2004.
dc.identifier.doi10.1590/S1806-83242004000300003
dc.identifier.file2-s2.0-23744512455.pdf
dc.identifier.issn1806-8324
dc.identifier.lattes5051118752980903
dc.identifier.lattes7528116925519142
dc.identifier.scieloS1806-83242004000300003
dc.identifier.scopus2-s2.0-23744512455
dc.identifier.urihttp://hdl.handle.net/11449/67789
dc.language.isoeng
dc.relation.ispartofPesquisa Odontológica Brasileira = Brazilian Oral Research
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectfluoride sodium
dc.subjectanimal
dc.subjectCHO cell
dc.subjectcomet assay
dc.subjectCricetulus
dc.subjectDNA damage
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthamster
dc.subjectAnimals
dc.subjectCHO Cells
dc.subjectComet Assay
dc.subjectCricetinae
dc.subjectDNA Damage
dc.subjectFemale
dc.subjectSodium Fluoride
dc.titleFluoride does not induce DNA breakage in Chinese hamster ovary cells in vitro.en
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/pob/paboutj.htm#Propriedade
unesp.author.lattes5051118752980903
unesp.author.lattes7528116925519142
unesp.author.orcid0000-0001-6947-5627[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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