Comparative genomic hybridization analysis detects frequent over-representation of DNA sequences at 3q, 7p, and 8q in head and neck carcinomas

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dc.contributor.authorBergamo, N. A.
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.authorPoli-Frederico, R. C.
dc.contributor.authorReis, Patricia Pintor dos [UNESP]
dc.contributor.authorKowalski, L. P.
dc.contributor.authorZielenska, M.
dc.contributor.authorSquire, J. A.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAC Camargo Hosp
dc.contributor.institutionUniv Toronto
dc.contributor.institutionOntario Canc Inst
dc.date.accessioned2014-05-20T15:19:48Z
dc.date.available2014-05-20T15:19:48Z
dc.date.issued2000-05-01
dc.description.abstractComparative genomic hybridization (CGH) was used to identify chromosomal imbalances in 19 samples of squamous cell carcinoma of the head and neck (HNSCC). The chromosome arms most often or er-represented were 3q (48%), 8q (42%), and 7p (32%); in many cases, these changes were observed at high copy number. Other commonly over-represented sites were 1q, 2q, 6p, 6q, and 18q. The most frequently under-represented segments were 3p and 22q. Loss of heterozygosity of two polymorphic microsatellite loci from chromosome 22 was observed in two tongue tumors, in agreement with the CGH analysis. Gains of 1q and 2q material were detected in patients exhibiting a clinical history of recurrence and/or metastasis followed by terminal disease. This association suggests that gain of 1q and 2q map be a new marker of head and neck tumors with a refractory clinical response. (C) 2000 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Genet, Inst Biociencias, UNESP,IB, BR-18618000 São Paulo, Brazil
dc.description.affiliationAC Camargo Hosp, Dept Head & Neck Surg, São Paulo, Brazil
dc.description.affiliationUniv Toronto, Hosp Sick Children, Dept Pediat Lab Med, Toronto, ON M5G 1X8, Canada
dc.description.affiliationUniv Toronto, Dept Med Biophys, Toronto, ON M5G 1X8, Canada
dc.description.affiliationUniv Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1X8, Canada
dc.description.affiliationOntario Canc Inst, Toronto, ON M4X 1K9, Canada
dc.description.affiliationUnespUniv Estadual Paulista, Dept Genet, Inst Biociencias, UNESP,IB, BR-18618000 São Paulo, Brazil
dc.format.extent48-55
dc.identifierhttp://dx.doi.org/10.1016/S0165-4608(99)00213-7
dc.identifier.citationCancer Genetics and Cytogenetics. New York: Elsevier B.V., v. 119, n. 1, p. 48-55, 2000.
dc.identifier.doi10.1016/S0165-4608(99)00213-7
dc.identifier.issn0165-4608
dc.identifier.lattes2259986546265579
dc.identifier.lattes1109525021631011
dc.identifier.orcid0000-0003-3775-3797
dc.identifier.urihttp://hdl.handle.net/11449/31182
dc.identifier.wosWOS:000087079600009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCancer Genetics and Cytogenetics
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleComparative genomic hybridization analysis detects frequent over-representation of DNA sequences at 3q, 7p, and 8q in head and neck carcinomasen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1109525021631011[4]
unesp.author.lattes2259986546265579
unesp.author.orcid0000-0003-3775-3797[4]
unesp.author.orcid0000-0002-0481-156X[5]
unesp.author.orcid0000-0001-5865-9308[5]
unesp.author.orcid0000-0002-9863-468X[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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