Effects of exposure to sediment-associated fipronil on cardiac function of Neotropical armored catfish Hypostomus regani

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dc.contributor.authorFerro, Lucas Abreu [UNESP]
dc.contributor.authorFernandes, Suzana Luisa Alves [UNESP]
dc.contributor.authorKalinin, Ana Lúcia
dc.contributor.authorMonteiro, Diana Amaral
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2023-07-29T13:43:03Z
dc.date.available2023-07-29T13:43:03Z
dc.date.issued2023-01-01
dc.description.abstractFipronil is widely used as a broad-spectrum insecticide in agriculture, urban environments, and veterinary medicine. Fipronil can enter aquatic ecosystems and spread to sediment and organic matter, representing a risk to non-target species. This study aimed to evaluate the effects of short-term (96 h) exposure to a low and realistic concentration of sediment-associated fipronil (4.2 µg.kg−1 of Regent® 800 WG) on myocardial contractility of armored catfish Hypostomus regain, a benthic fish species. Fipronil exposure induced increased inotropism and acceleration of contractile kinetics, although no alterations in the relative ventricular mass were observed. This better cardiac function was associated with an elevated expression and/or function of the Na+/Ca2+ exchanger and its marked contribution to contraction and relaxation, probably due to a stress-induced adrenergic stimulation. Ventricle strips of exposed fish also exhibited a faster relaxation and a higher cardiac pumping capacity, indicating that armored catfish were able to perform cardiac adjustments to face the exposure. However, a high energetic cost to maintain an increased cardiac performance can make fish more susceptible to other stressors, impairing developmental processes and/or survival. These findings highlight the need for regulations of emerging contaminants, such as fipronil, to ensure adequate protection of the aquatic system.en
dc.description.affiliationJoint Graduate Program in Physiological Sciences Federal University of São Carlos (UFSCar) São Paulo State University (UNESP), Araraquara
dc.description.affiliationDepartment of Physiological Sciences Federal University of São Carlos (UFSCar), São Paulo
dc.description.affiliationUnespJoint Graduate Program in Physiological Sciences Federal University of São Carlos (UFSCar) São Paulo State University (UNESP), Araraquara
dc.format.extent236-245
dc.identifierhttp://dx.doi.org/10.1080/10934529.2023.2182582
dc.identifier.citationJournal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, v. 58, n. 3, p. 236-245, 2023.
dc.identifier.doi10.1080/10934529.2023.2182582
dc.identifier.issn1532-4117
dc.identifier.issn1093-4529
dc.identifier.scopus2-s2.0-85148600027
dc.identifier.urihttp://hdl.handle.net/11449/248400
dc.language.isoeng
dc.relation.ispartofJournal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
dc.sourceScopus
dc.subjectcalcium handling
dc.subjectcardiac pumping capacity
dc.subjectcontaminated sediments
dc.subjectcontractile force
dc.subjectexcitation-contraction coupling
dc.subjectfish
dc.subjectheart
dc.subjectInsecticide
dc.subjectNa+/Ca2+ exchanger
dc.subjectphysiological biomarkers
dc.titleEffects of exposure to sediment-associated fipronil on cardiac function of Neotropical armored catfish Hypostomus reganien
dc.typeArtigo
unesp.author.orcid0000-0002-1178-6673[4]

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