Protumorigenic M2-like phenotype cell infiltration in the melanotic neuroectodermal tumor of infancy This work was presented as poster in XXIII Brazilian Congress of Stomatology and Oral Pathology in July, 2015.

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dc.contributor.authorStrieder, Luciana [UNESP]
dc.contributor.authorCarlos, Román
dc.contributor.authorLeón, Jorge Esquiche
dc.contributor.authorRibeiro-Silva, Alfredo
dc.contributor.authorCosta, Victor [UNESP]
dc.contributor.authorKaminagakura, Estela [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionDirct. of Centro Clínico de Cabeza y Cuello
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:22:59Z
dc.date.available2018-12-11T17:22:59Z
dc.date.issued2016-02-01
dc.description.abstractObjective The aim of this study is to report 2 cases of melanotic neuroectodermal tumor of infancy (MNTI), emphasizing the analysis of intratumoral immune cells by immunohistochemistry. Study Design Case 1: A 6-month-old girl presented with a 3-cm tumor in the anterior region of the left maxilla. Case 2: A 4-month-old boy presented with a 4-cm tumor in the anterior region of the left maxilla. Microscopically, case 1 had predominantly neuroblast-like cells supported by fibrillary neuropil-like stroma arranged in an alveolar pattern, whereas case 2 exhibited scattered melanocyte-like and neuroblast-like cells supported by fibrovascular stroma. A large immunohistochemical panel for characterizing intratumoral macrophage and dendritic cell subsets was performed. Results Immunohistochemical analysis indicated positivity for HLA-DR, XIIIa, CD68, and CD163 (range 6%-50%) mainly on the fibrovascular stroma, suggesting M2 macrophage-like cell phenotype. CD138 was overexpressed in the tumor stroma. Conclusions Results suggest the involvement of M2-polarized macrophages in the MNTI pathogenesis, which may act by modulating tumor growth and/or tumor stromal remodeling.en
dc.description.affiliationMaster Stud. of Oral Biopathology Institute of Science and Technology UNESP-Univ Estadual Paulista School of Dentistry
dc.description.affiliationDirct. of Centro Clínico de Cabeza y Cuello
dc.description.affiliationDepartment of Stomatology Public Oral Health and Forensic Dentistry University of São Paulo Ribeirão Preto School of Dentistry
dc.description.affiliationDepartment of Pathology Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology UNESP-Univ Estadual Paulista School of Dentistry
dc.description.affiliationDepartment of Bioscience and Oral Diagnosis Science and Technology Institute University of São Paulo State, Av. Eng. Francisco Jos Longo n- 777
dc.description.affiliationUnespMaster Stud. of Oral Biopathology Institute of Science and Technology UNESP-Univ Estadual Paulista School of Dentistry
dc.description.affiliationUnespDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology UNESP-Univ Estadual Paulista School of Dentistry
dc.format.extent173-179
dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2015.09.015
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, v. 121, n. 2, p. 173-179, 2016.
dc.identifier.doi10.1016/j.oooo.2015.09.015
dc.identifier.file2-s2.0-84955329286.pdf
dc.identifier.issn2212-4403
dc.identifier.scopus2-s2.0-84955329286
dc.identifier.urihttp://hdl.handle.net/11449/176897
dc.language.isoeng
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.relation.ispartofsjr0,720
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleProtumorigenic M2-like phenotype cell infiltration in the melanotic neuroectodermal tumor of infancy This work was presented as poster in XXIII Brazilian Congress of Stomatology and Oral Pathology in July, 2015.en
dc.typeTrabalho apresentado em evento

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