Inflammatory bowel disease and oral health: systematic review and a meta-analysis

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dc.contributor.authorPapageorgiou, Spyridon N.
dc.contributor.authorHagner, Martin
dc.contributor.authorNogueira, Andressa Vilas Boas [UNESP]
dc.contributor.authorFranke, Andre
dc.contributor.authorJäger, Andreas
dc.contributor.authorDeschner, James
dc.contributor.institutionUniversity of Zurich
dc.contributor.institutionPrivate Practice
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionChristian-Albrechts-University of Kiel
dc.contributor.institutionUniversity of Bonn
dc.date.accessioned2018-12-11T16:46:13Z
dc.date.available2018-12-11T16:46:13Z
dc.date.issued2017-04-01
dc.description.abstractBackground: The objective of this systematic review was to systematically investigate whether there is an association between inflammatory bowel disease (IBD) and oral health. Methods: Literature searches for randomized and non-randomized studies were performed up to January 2017. Risk of bias within studies was assessed with the Downs and Black checklist. Across-studies risk of bias was assessed with the GRADE framework. Quantitative synthesis was conducted with random-effects meta-analyses. Results: A total of 9 cross-sectional studies including 1297 patients were included. IBD was associated with increased risk of periodontitis (332 more patients per 1000 patients; 95% confidence interval (CI): 257–388 patients; p < 0.001) compared to non-IBD patients. Additionally, the Decayed-Missing-Filled-Teeth index of IBD patients was significantly worse than non-IBD patients (mean difference: 3.85; 95% CI: 2.36–5.34; p = 0.005). Patients with ulcerative colitis had considerably worse oral health for most of the assessed factors, while the quality of overall evidence ranged from high to low, due to the observational nature of contributing studies. Conclusions: Inflammatory bowel disease was associated with significantly higher risk of periodontitis and worse oral health compared to non-IBD patients. However, longitudinal studies are needed in order to establish a causality link between IBD and periodontal disease.en
dc.description.affiliationClinic of Orthodontics and Pediatric Dentistry Center of Dental Medicine University of Zurich
dc.description.affiliationPrivate Practice
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry UNESP Univ Estadual Paulista
dc.description.affiliationInstitute of Clinical Molecular Biology Christian-Albrechts-University of Kiel
dc.description.affiliationDepartment of Orthodontics School of Dentistry University of Bonn
dc.description.affiliationSection of Experimental Dento-Maxillo-Facial Medicine School of Dentistry University of Bonn
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry UNESP Univ Estadual Paulista
dc.format.extent382-393
dc.identifierhttp://dx.doi.org/10.1111/jcpe.12698
dc.identifier.citationJournal of Clinical Periodontology, v. 44, n. 4, p. 382-393, 2017.
dc.identifier.doi10.1111/jcpe.12698
dc.identifier.issn1600-051X
dc.identifier.issn0303-6979
dc.identifier.scopus2-s2.0-85014460623
dc.identifier.urihttp://hdl.handle.net/11449/169513
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Periodontology
dc.relation.ispartofsjr2,079
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCrohn's disease
dc.subjectinflammatory bowel disease
dc.subjectmeta-analysis
dc.subjectoral health
dc.subjectperiodontal disease
dc.subjectsystematic review
dc.subjectulcerative colitis
dc.titleInflammatory bowel disease and oral health: systematic review and a meta-analysisen
dc.typeResenha
unesp.author.orcid0000-0003-1968-3326[1]

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