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Highly Sensitive Neurotransmitters Analysis at Platinum-Ultramicroelectrodes Arrays

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dc.contributor.authorMoraes, Fernando C.
dc.contributor.authorCesarino, Ivana
dc.contributor.authorCoelho, Dyovani
dc.contributor.authorPedrosa, Valber A. [UNESP]
dc.contributor.authorMachado, Sergio A. S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:53:34Z
dc.date.available2014-05-20T13:53:34Z
dc.date.issued2012-05-01
dc.description.abstractAn easy way to determine norepinephrine (NE) in biological fluid using a platinum ultramicroelectrode array (Pt-UMEAs) is described. Issues related to UME electrode surface treatment and characterizations are also addressed. At optimized experimental conditions the dynamic concentration range was 1.0 to 10.0 mu mol?L-1 with a detection limit of 40.5 nmol?L-1. The repeatability of current responses for injections of 5 mu mol?L-1 NE was evaluated to be 4.0?% (n=10). This approach obtained excellent sensitivity, a reliable calibration profile and stable electrochemical response for norepinephrine detection. The content of NE in urine samples without any preconcentration, purification, or pretreatment step, was successfully analyzed by the standard addition method using the Pt-UMEAs.en
dc.description.affiliationUniv São Paulo, Inst Quim São Carlos, São Carlos, SP, Brazil
dc.description.affiliationUNESP, Dept Chem & Biochem, Inst Biosci, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Chem & Biochem, Inst Biosci, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 10/11567-3
dc.description.sponsorshipIdFAPESP: 10/11049-2
dc.description.sponsorshipIdFAPESP: 10/07478-5
dc.format.extent1115-1120
dc.identifierhttp://dx.doi.org/10.1002/elan.201200011
dc.identifier.citationElectroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 24, n. 5, p. 1115-1120, 2012.
dc.identifier.doi10.1002/elan.201200011
dc.identifier.issn1040-0397
dc.identifier.lattes7781282422851911
dc.identifier.urihttp://hdl.handle.net/11449/19119
dc.identifier.wosWOS:000303439500018
dc.language.isoeng
dc.publisherWiley-v C H Verlag Gmbh
dc.relation.ispartofElectroanalysis
dc.relation.ispartofjcr2.851
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPlatinum ultramicroelectrode arrayen
dc.subjectNorepinephrineen
dc.subjectBiological fluidsen
dc.titleHighly Sensitive Neurotransmitters Analysis at Platinum-Ultramicroelectrodes Arraysen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-v C H Verlag Gmbh
dspace.entity.typePublication
unesp.author.lattes7781282422851911
unesp.author.orcid0000-0002-0172-3759[2]
unesp.author.orcid0000-0002-2296-3671[2]
unesp.author.orcid0000-0002-1652-7144[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentQuímica e Bioquímica - IBBpt

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Botucatu - IBB - Instituto de Biociências