Intraarticular Epsilon Aminocaproic Acid Versus Tranexamic Acid In Total Knee Arthroplasty

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dc.contributor.authorGuerreiro, Joao Paulo Fernandes [UNESP]
dc.contributor.authorBalbino, Jose Rodolfo Martines
dc.contributor.authorRodrigues, Bruno Possani
dc.contributor.authorDanieli, Marcus Vinicius [UNESP]
dc.contributor.authorQueiroz, Alexandre Oliveira
dc.contributor.authorCataneo, Daniele Cristina [UNESP]
dc.contributor.institutionUniort.e Orthopedic Hospital
dc.contributor.institutionLondrina Evangelic Hospital
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:48:15Z
dc.date.available2022-04-28T19:48:15Z
dc.date.issued2021-01-01
dc.description.abstractObjective: To examine and compare the clinical efficacy of intraarticular epsilon aminocaproic acid (EACA) and tranexamic acid (TXA) in total knee arthroplasty (TKA). Methods: This study was a prospective, single-center, double-blinded randomized controlled trial, including sixty patients with osteoarthritis of the knee divided into two groups of 30 patients. In the TXA group, 1 g of TXA (0.05 g/ ml) was applied intraarticularly, and in the EACA group, 4 g of EACA (0.2 g/ml) was applied intraarticularly. Serum hemoglobin (Hgb) and hematocrit (Htb) were measured during the preoperatively and 24 and 48 hours postoperatively. The range of motion and pain were evaluated by clinical examination. To evaluate knee function before and 2 months after surgery, the Western Ontario and McMaster Universities Index (WOMAC) questionnaire was used. Results: In total, 56 (93.3%) patients were evaluated up to the second postoperative month. No significant difference between the groups (p > 0.05) was found in the decrease in Hgb or Htb at 24 or 48 hours. Regarding assessment of the pain, WOMAC score and gain in knee flexion, no significant advantages up to 60 days after surgery (p > 0.05) were found. Conclusions: The decrease risk of transfusion were similar with the intraarticular use of 1 g of TXA and 4 g of EACA in TKA. The possible benefits regarding knee pain, gain in flexion and function were also similar for the drugs. Level of Evidence II, Randomized, Double-Blinded, Clinical Trial.en
dc.description.affiliationUniort.e Orthopedic Hospital
dc.description.affiliationLondrina Evangelic Hospital
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho
dc.format.extent312-315
dc.identifierhttp://dx.doi.org/10.1590/1413-785220212906242008
dc.identifier.citationActa Ortopedica Brasileira, v. 29, n. 6, p. 312-315, 2021.
dc.identifier.doi10.1590/1413-785220212906242008
dc.identifier.issn1413-7852
dc.identifier.scopus2-s2.0-85121011374
dc.identifier.urihttp://hdl.handle.net/11449/223032
dc.language.isoeng
dc.relation.ispartofActa Ortopedica Brasileira
dc.sourceScopus
dc.subjectBleeding
dc.subjectEpsilon Aminocaproic Acid
dc.subjectPain
dc.subjectTotal Knee Arthroplasty
dc.subjectTranexamic Acid
dc.titleIntraarticular Epsilon Aminocaproic Acid Versus Tranexamic Acid In Total Knee Arthroplastyen
dc.titleAcido Épsilon Aminocaproico Intra-Articular Versus Acido Tranexâmico Na Prótese Total Do Joelhopt
dc.typeArtigo
unesp.author.orcid0000-0002-2026-9176 0000-0002-2026-9176 0000-0002-2026-9176[1]
unesp.author.orcid0000-0001-6608-7864[2]
unesp.author.orcid0000-0003-2990-7901[3]
unesp.author.orcid0000-0001-7547-7557 0000-0001-7547-7557 0000-0001-7547-7557[4]
unesp.author.orcid0000-0003-2808-7892[5]
unesp.author.orcid0000-0002-3400-2309[6]

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