Hypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockage

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dc.contributor.authorMelo Morais, Ingrid Beatriz de
dc.contributor.authorSilva, Denise Brentan
dc.contributor.authorCarollo, Carlos Alexandre
dc.contributor.authorFerreira-Neto, Marcos Luiz
dc.contributor.authorFidelis-de-Oliveira, Patricia [UNESP]
dc.contributor.authorBispo-da-Silva, Luiz Borges
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T19:50:51Z
dc.date.available2020-12-10T19:50:51Z
dc.date.issued2020-02-20
dc.description.abstractThe ability of Campomanesia xanthocarpa leaf extract (CXLE) to alter blood pressure and heart rate was evaluated in anesthetized rats. The CXLE-induced hypotension was evaluated before and after losartan, methylatropine, L-N(omega)-nitro-L-arginine methyl ester (L-NAME), hexamethonium, indomethacin, glibenclamide, or nifedipine administration. The constituents of CXLE were identified by LC-DAD-MS. CXLE decreased blood pressure in a dose-dependent manner; only the highest dose decreased heart rate. The hypotension induced by CXLE was sensitive only to losartan, nifedipine, and glibenclamide. L-NAME decreased the time to recover 50% of the hypotensive effect of CXLE without altering its magnitude. Flavan-3-ols, proanthocyanidins (dimers and trimers), and glycosylated flavonols were identified from CXLE. The chemical constituents of CXLE seem to induce not only angiotensin II type 1 receptor blockage, but also ATP-sensitive potassium channels activation and L-type voltage-dependent Ca2+ channels inactivation. Nitric oxide is involved in the maintenance of the hypotensive effect of CXLE.en
dc.description.affiliationFed Univ Uberlandia UFU, Inst Biomed Sci, Dept Pharmacol, Campus Umuarama, Uberlandia, MG, Brazil
dc.description.affiliationFed Univ Mato Grosso UFMS, Lab Prod Nat & Espectrometria Massas LAPNEM, Campo Grande, MS, Brazil
dc.description.affiliationFed Univ Uberlandia UFU, Inst Biomed Sci, Dept Physiol, Campus Umuarama, Uberlandia, MG, Brazil
dc.description.affiliationSao Paulo State Univ, UNESP, Inst Biosci, Dept Physiol, Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Inst Biosci, Dept Physiol, Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)
dc.description.sponsorshipIdCNPq: IC-CNPQ2014-0352
dc.format.extent5
dc.identifierhttp://dx.doi.org/10.1080/14786419.2020.1727467
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, 5 p., 2020.
dc.identifier.doi10.1080/14786419.2020.1727467
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/11449/196623
dc.identifier.wosWOS:000516517200001
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.sourceWeb of Science
dc.subjectCardiovascular
dc.subjectpotassium channels
dc.subjectcalcium channels
dc.subjectflavan-3-ols
dc.subjectproanthocyanidins
dc.subjectglycosylated flavonols
dc.titleHypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockageen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd

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