Hypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockage
dc.contributor.author | Melo Morais, Ingrid Beatriz de | |
dc.contributor.author | Silva, Denise Brentan | |
dc.contributor.author | Carollo, Carlos Alexandre | |
dc.contributor.author | Ferreira-Neto, Marcos Luiz | |
dc.contributor.author | Fidelis-de-Oliveira, Patricia [UNESP] | |
dc.contributor.author | Bispo-da-Silva, Luiz Borges | |
dc.contributor.institution | Universidade Federal de Uberlândia (UFU) | |
dc.contributor.institution | Universidade Federal de Mato Grosso do Sul (UFMS) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2020-12-10T19:50:51Z | |
dc.date.available | 2020-12-10T19:50:51Z | |
dc.date.issued | 2020-02-20 | |
dc.description.abstract | The ability of Campomanesia xanthocarpa leaf extract (CXLE) to alter blood pressure and heart rate was evaluated in anesthetized rats. The CXLE-induced hypotension was evaluated before and after losartan, methylatropine, L-N(omega)-nitro-L-arginine methyl ester (L-NAME), hexamethonium, indomethacin, glibenclamide, or nifedipine administration. The constituents of CXLE were identified by LC-DAD-MS. CXLE decreased blood pressure in a dose-dependent manner; only the highest dose decreased heart rate. The hypotension induced by CXLE was sensitive only to losartan, nifedipine, and glibenclamide. L-NAME decreased the time to recover 50% of the hypotensive effect of CXLE without altering its magnitude. Flavan-3-ols, proanthocyanidins (dimers and trimers), and glycosylated flavonols were identified from CXLE. The chemical constituents of CXLE seem to induce not only angiotensin II type 1 receptor blockage, but also ATP-sensitive potassium channels activation and L-type voltage-dependent Ca2+ channels inactivation. Nitric oxide is involved in the maintenance of the hypotensive effect of CXLE. | en |
dc.description.affiliation | Fed Univ Uberlandia UFU, Inst Biomed Sci, Dept Pharmacol, Campus Umuarama, Uberlandia, MG, Brazil | |
dc.description.affiliation | Fed Univ Mato Grosso UFMS, Lab Prod Nat & Espectrometria Massas LAPNEM, Campo Grande, MS, Brazil | |
dc.description.affiliation | Fed Univ Uberlandia UFU, Inst Biomed Sci, Dept Physiol, Campus Umuarama, Uberlandia, MG, Brazil | |
dc.description.affiliation | Sao Paulo State Univ, UNESP, Inst Biosci, Dept Physiol, Botucatu, SP, Brazil | |
dc.description.affiliationUnesp | Sao Paulo State Univ, UNESP, Inst Biosci, Dept Physiol, Botucatu, SP, Brazil | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT) | |
dc.description.sponsorshipId | CNPq: IC-CNPQ2014-0352 | |
dc.format.extent | 5 | |
dc.identifier | http://dx.doi.org/10.1080/14786419.2020.1727467 | |
dc.identifier.citation | Natural Product Research. Abingdon: Taylor & Francis Ltd, 5 p., 2020. | |
dc.identifier.doi | 10.1080/14786419.2020.1727467 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | http://hdl.handle.net/11449/196623 | |
dc.identifier.wos | WOS:000516517200001 | |
dc.language.iso | eng | |
dc.publisher | Taylor & Francis Ltd | |
dc.relation.ispartof | Natural Product Research | |
dc.source | Web of Science | |
dc.subject | Cardiovascular | |
dc.subject | potassium channels | |
dc.subject | calcium channels | |
dc.subject | flavan-3-ols | |
dc.subject | proanthocyanidins | |
dc.subject | glycosylated flavonols | |
dc.title | Hypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockage | en |
dc.type | Artigo | |
dcterms.license | http://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp | |
dcterms.rightsHolder | Taylor & Francis Ltd |