SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System

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dc.contributor.authorOliveira, Kellysson Bruno
dc.contributor.authorMelo, Igor Santana de
dc.contributor.authorSilva, Bianca Rodrigues Melo da
dc.contributor.authorOliveira, Keylla Lavínia da Silva
dc.contributor.authorSabino-Silva, Robinson
dc.contributor.authorAnhezini, Lucas
dc.contributor.authorKatayama, Pedro Lourenco [UNESP]
dc.contributor.authorSantos, Victor Rodrigues
dc.contributor.authorShetty, Ashok K
dc.contributor.authorCastro, Olagide Wagner de
dc.contributor.institutionFederal University of Alagoas (UFAL)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionFederal University of Alagoas
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionTexas AM University School of Medicine
dc.date.accessioned2023-07-29T13:40:14Z
dc.date.available2023-07-29T13:40:14Z
dc.date.issued2023-01-01
dc.description.abstractHypertension is considered one of the most critical risk factors for COVID-19. Evidence suggests that SARS-CoV-2 infection produces intense effects on the cardiovascular system by weakening the wall of large vessels via vasa-vasorum. In this commentary, we propose that SARS-CoV-2 invades carotid and aortic baroreceptors, leading to infection of the nucleus tractus solitari (NTS) and paraventricular hypothalamic nucleus (PVN), and such dysregulation of NTS and PVN following infection causes blood pressure alteration at the central level. We additionally explored the hypothesis that SARS-CoV-2 favors the internalization of membrane ACE2 receptors generating an imbalance of the renin-angiotensin-aldosterone system (RAAS), increasing the activity of angiotensin II (ANG-II), disintegrin, and metalloproteinase 17 domain (ADAM17/TACE), eventually modulating the integration of afferents reaching the NTS from baroreceptors and promoting increased blood pressure. These mechanisms are related to the increased sympathetic activity, which leads to transient or permanent hypertension associated with SARS-CoV-2 invasion, contributing to the high number of deaths by cardiovascular implications.en
dc.description.affiliationDepartment of Physiology Institute of Biological Sciences and Health Federal University of Alagoas (UFAL), Alagoas
dc.description.affiliationDepartment of Physiology Institute of Biomedical Sciences Federal University of Uberlandia (UFU), Minas Gerais
dc.description.affiliationDepartment of Histology Institute of Biological Sciences and Health Federal University of Alagoas, Alagoas
dc.description.affiliationDepartment of Physiology and Pathology Dentistry School of Araraquara São Paulo State University
dc.description.affiliationDepartment of Morphology Institute of Biological Science Federal University of Minas Gerais (UFMG), Minas Gerais
dc.description.affiliationInstitute for Regenerative Medicine Department of Cell Biology and Genetics Texas AM University School of Medicine
dc.description.affiliationUnespDepartment of Physiology and Pathology Dentistry School of Araraquara São Paulo State University
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Alagoas
dc.identifierhttp://dx.doi.org/10.1177/26331055231151926
dc.identifier.citationNeuroscience Insights, v. 18.
dc.identifier.doi10.1177/26331055231151926
dc.identifier.issn2633-1055
dc.identifier.scopus2-s2.0-85147431703
dc.identifier.urihttp://hdl.handle.net/11449/248307
dc.language.isoeng
dc.relation.ispartofNeuroscience Insights
dc.sourceScopus
dc.subjectangiotensin II
dc.subjectbaroreflex
dc.subjecthypertension
dc.subjectSARS-CoV-2
dc.titleSARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-Systemen
dc.typeNota
unesp.author.orcid0000-0001-5049-6671[9]
unesp.author.orcid0000-0002-1874-509X[10]

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