Vulvar carcinoma in young patients and its relationship with genital warts

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dc.contributor.authorTraiman, Paulo [UNESP]
dc.contributor.authorBacchi, C. E.
dc.contributor.authorDe Luca, L. A.
dc.contributor.authorUemura, Gilberto [UNESP]
dc.contributor.authorNahas Neto, Jorge [UNESP]
dc.contributor.authorNahas, EAP
dc.contributor.authorPontes, Anaglória [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:06Z
dc.date.available2014-05-20T13:35:06Z
dc.date.issued1999-01-01
dc.description.abstractWe report the occurrence of aggressive vulvar carcinoma associated with condyloma acuminata in three patients: under 33 years old. Discussion of the role of the human papilloma virus (HPV) in the development of vulvar cancer is also presented. Three patients with condyloma associated with aggressive vulvar squamous cell carcinoma, in situ (1 case) and invasive (2 cases), documented by biopsy and/or vulvectomy are presented. In situ hybridization (ISH) was used to characterize the subtypes of HPV. One patient with erythematous systemic lupus developed in situ carcinoma after 5 years. The other two cases also developed aggressive multicentric, invasive squamous cell carcinoma after 10 years of diagnosis of condyloma. In all cases HPV cytological abnormalities were seen throughout the pathological examination. HPV 16 and 18 were present in cells of invasive squamous cell carcinoma in cases 2 and 3. HPV 6 and 11 were detected only in the condyloma area in case 2. HPV 30 was seen only in the condyloma area in case 3. This report emphasizes the need for biopsies of all unusually persistent or treatment-resistant condylomas, particularly in young and/or immunoisuppressed patients.en
dc.description.affiliationUNESP, Fac Med, Dept Obstet & Ginecol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Med, Dept Obstet & Ginecol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Pathol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent191-194
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10410883
dc.identifier.citationEuropean Journal of Gynaecological Oncology. Montreal: S O G Canada Inc., v. 20, n. 3, p. 191-194, 1999.
dc.identifier.issn0392-2936
dc.identifier.lattes8334785337106990
dc.identifier.lattes9878648143577124
dc.identifier.lattes4155170574788417
dc.identifier.lattes0514178654667684
dc.identifier.urihttp://hdl.handle.net/11449/12057
dc.identifier.wosWOS:000080986700008
dc.language.isoeng
dc.publisherS O G Canada Inc
dc.relation.ispartofEuropean Journal of Gynaecological Oncology
dc.relation.ispartofjcr0.617
dc.relation.ispartofsjr0,301
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectin situ hybridizationpt
dc.subjectHPVpt
dc.subjectvulvarpt
dc.subjectcarcinomapt
dc.subjectyoung patientspt
dc.titleVulvar carcinoma in young patients and its relationship with genital wartsen
dc.typeArtigo
dcterms.licensehttp://www.irog.net/about
dcterms.rightsHolderS O G Canada Inc
unesp.author.lattes8334785337106990
unesp.author.lattes9878648143577124
unesp.author.lattes4155170574788417
unesp.author.lattes0514178654667684
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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