Vernonia polyanthes as a new source of antiulcer drugs
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Data
2007-12-01
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Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.
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Action mechanisms , Antiulcerogenic activity , Vernonia polyanthes , alcohol , antiulcer agent , carbenoxolone , cimetidine , lansoprazole , n ethylmaleimide , n(g) nitroarginine methyl ester , nonsteroid antiinflammatory agent , piroxicam , plant extract , unclassified drug , vernonia polyanthes chloroformic extract , Vernonia polyanthes extract , vernonia polyanthes methanolic extract , animal experiment , animal model , drug inhibition , drug mechanism , male , medicinal plant , mouse , nonhuman , priority journal , rat , stomach mucosa lesion , vernonia polyanthes , Animals , Anti-Inflammatory Agents, Non-Steroidal , Anti-Ulcer Agents , Dose-Response Relationship, Drug , Ethanol , Male , Phytotherapy , Plant Components, Aerial , Plant Extracts , Rats , Rats, Wistar , Stomach Ulcer , Vernonia
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Inglês
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Fitoterapia, v. 78, n. 7-8, p. 545-551, 2007.