Vernonia polyanthes as a new source of antiulcer drugs

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dc.contributor.authorBarbastefano, Victor
dc.contributor.authorCola, Maira
dc.contributor.authorLuiz-Ferreira, Anderson
dc.contributor.authorFarias-Silva, Elisângela
dc.contributor.authorHiruma-Lima, Clélia A. [UNESP]
dc.contributor.authorRinaldo, Daniel [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorSouza-Brito, Alba R.M.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:39Z
dc.date.available2014-05-27T11:22:39Z
dc.date.issued2007-12-01
dc.description.abstractMethanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationDepartamento de Fisiologia e Biofísica Instituto de Biologia Universidade Estadual de Campinas (UNICAMP), Cidade Universitaria Zeferino Vaz, s/n, CP 6109, CEP13083-970 Campinas, SP
dc.description.affiliationDepartamento de Fisiologia Instituto de Biociências Universidade Estadual Paulista (UNESP), Botucatu, SP
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, SP
dc.description.affiliationUnespDepartamento de Fisiologia Instituto de Biociências Universidade Estadual Paulista (UNESP), Botucatu, SP
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, SP
dc.format.extent545-551
dc.identifierhttp://dx.doi.org/10.1016/j.fitote.2007.07.003
dc.identifier.citationFitoterapia, v. 78, n. 7-8, p. 545-551, 2007.
dc.identifier.doi10.1016/j.fitote.2007.07.003
dc.identifier.issn0367-326X
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scopus2-s2.0-35448985425
dc.identifier.urihttp://hdl.handle.net/11449/70008
dc.language.isoeng
dc.relation.ispartofFitoterapia
dc.relation.ispartofjcr2.642
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAction mechanisms
dc.subjectAntiulcerogenic activity
dc.subjectVernonia polyanthes
dc.subjectalcohol
dc.subjectantiulcer agent
dc.subjectcarbenoxolone
dc.subjectcimetidine
dc.subjectlansoprazole
dc.subjectn ethylmaleimide
dc.subjectn(g) nitroarginine methyl ester
dc.subjectnonsteroid antiinflammatory agent
dc.subjectpiroxicam
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectvernonia polyanthes chloroformic extract
dc.subjectVernonia polyanthes extract
dc.subjectvernonia polyanthes methanolic extract
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectdrug inhibition
dc.subjectdrug mechanism
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectstomach mucosa lesion
dc.subjectvernonia polyanthes
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectAnti-Ulcer Agents
dc.subjectDose-Response Relationship, Drug
dc.subjectEthanol
dc.subjectMale
dc.subjectPhytotherapy
dc.subjectPlant Components, Aerial
dc.subjectPlant Extracts
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStomach Ulcer
dc.subjectVernonia
dc.titleVernonia polyanthes as a new source of antiulcer drugsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes3814504901386844[5]
unesp.author.orcid0000-0002-8645-3777[5]
unesp.author.orcid0000-0003-3032-2556[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Fisiologia - IBB
Artigos - Química Orgânica - IQ