Hypothyroidism and acute kidney injury: An unusual association

dc.contributor.authorDe Menezes Neves, Precil Diego Miranda [UNESP]
dc.contributor.authorBridi, Ramaiane Aparecida [UNESP]
dc.contributor.authorBalbi, André Luis [UNESP]
dc.contributor.authorPonce, Daniela [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:08Z
dc.date.available2014-05-27T11:30:08Z
dc.date.issued2013-08-09
dc.description.abstractAssociation between severe hypothyroidism and acute kidney injury (AKI) is rare. A 40-year-old woman presented with 15 days history of generalised muscle pain, weakness, weight gain and oedema. Medical history: hypertension and hypothyroidism. Physical examination: dry skin, peripheral/periorbital oedema, slow thought and speaking, thyroid increased. Laboratory examinations: high levels of creatine kinase , creatinine, uric acid and lactate dehydrogenase. Free T4 was very low (<0.3 ng/dL) and thyroid-stimulating hormone was high (21.7 mIU/mL). Urinalysis showed haem pigment without haematuria. We performed the diagnosis of AKI secondary to hypothyroidism-induced rhabdomyolysis. Intravenous fluids were started, urinary alkalisation and increased l-thyroxine dose replacement. On the day after admission, forced diuresis with furosemide was introduced leading to a progressive improvement of symptoms. Although hypothyroidism and AKI is unusual, it should be suspected in patients presenting decrease of renal function and high creatine kinase in the absence of other causes of rhabdomyolysis.en
dc.description.affiliationDepartment of Internal Medicine University São Paulo State-UNESP, Botucatu, Sao Paulo
dc.description.affiliationUnespDepartment of Internal Medicine University São Paulo State-UNESP, Botucatu, Sao Paulo
dc.identifierhttp://dx.doi.org/10.1136/bcr-2013-200585
dc.identifier.citationBMJ Case Reports.
dc.identifier.doi10.1136/bcr-2013-200585
dc.identifier.issn1757-790X
dc.identifier.lattes5697804493071661
dc.identifier.scopus2-s2.0-84884237294
dc.identifier.urihttp://hdl.handle.net/11449/76245
dc.language.isoeng
dc.relation.ispartofBMJ Case Reports
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.titleHypothyroidism and acute kidney injury: An unusual associationen
dc.typeArtigo
dcterms.licensehttp://www.bmj.com/about-bmj/resources-authors
unesp.author.lattes5697804493071661[3]
unesp.author.orcid0000-0001-8366-5064[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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